Thorsteinsdottir Sigrun, Bjerrum Ole Weis, Hasselbalch Hans Carl
Department of Hematology, Roskilde Hospital, University of Copenhagen, Denmark.
Department of Hematology L, Rigshospitalet, University of Copenhagen, Denmark.
Leuk Res Rep. 2013 Jul 31;2(2):61-3. doi: 10.1016/j.lrr.2013.06.004. eCollection 2013.
The concurrence of myeloproliferative neoplasms (MPNs) and multiple sclerosis (MS) is unusual. We report five patients from a localized geographic area in Denmark with both MS and MPN; all the patients were diagnosed with MPNs in the years 2007-2012. We describe the patients' history and treatment. A potential link between MS and MPNs has not been previously recognized. This observation calls attention to potential environmental factors and/or previously unrecognized genetic factors predisposing these patients to both MS and MPNs.
骨髓增殖性肿瘤(MPN)与多发性硬化症(MS)同时出现的情况并不常见。我们报告了来自丹麦一个局部地理区域的五名同时患有MS和MPN的患者;所有患者均在2007年至2012年期间被诊断出患有MPN。我们描述了这些患者的病史和治疗情况。此前尚未认识到MS与MPN之间可能存在的联系。这一观察结果提醒人们注意可能导致这些患者同时罹患MS和MPN的潜在环境因素和/或此前未被认识的遗传因素。