Wang Yunhui, Zhao Xiaomiao, Zhao Huidan, Ding Hong, Tan Jianping, Chen Jingte, Zhang Rui, Azziz Ricardo, Yang Dongzi
Department of Obstetrics and Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.
The Medical College of Georgia, Augusta, GA 30912, USA.
Biomed Res Int. 2013;2013:182582. doi: 10.1155/2013/182582. Epub 2013 Nov 25.
To evaluate pregnancy outcomes and its determinants in women with polycystic ovary syndrome (PCOS).
Two-hundred and twenty pregnant PCOS and 594 healthy women were followed from early pregnancy. Incidences of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preterm birth, twinning, and fetal growth restriction (FGR) were determined.
The incidence of GDM was notably higher among all PCOS combined (54.9%; OR: 2.9, 95% CI: 2.0-4.1) and PCOS subgroups, whether they conceived spontaneously (51.5%; OR: 3.3, 95% CI: 2.0-5.4), or via IVF-ET or ovarian stimulation, compared with controls (14.3%; P < 0.001). The incidence of PIH was also higher among all PCOS (10.4%; OR: 2.2, 95% CI: 1.1-4.4) and the subgroup conceiving spontaneously (11.8%; OR: 2.6, 95% CI: 1.1-6.2; P < 0.001) but not for those conceiving with IVF-ET (9.1%) or ovarian stimulation (9.4%). Lean women with PCOS (BMI <24 kg/m(2)) had higher incidences of GDM (51.1% versus 14.5%; OR: 5.6, 95% CI: 3.4-9.0) and PIH (8.9% versus 3.2%; OR: 3.0, 95% CI: 1.3-7.1) than lean controls. PCOS women with normal glucose tolerance had higher risk for PIH than their comparable control group (OR: 4.0, 95% CI: 1.3-11.7).
This study suggested that PCOS is an independent risk factor for the development of GDM and PIH. This trial is registered with ChiCTR-RCC-11001824.
评估多囊卵巢综合征（PCOS）女性的妊娠结局及其决定因素。
从妊娠早期开始对220例PCOS孕妇和594例健康女性进行随访。确定妊娠期糖尿病（GDM）、妊娠高血压（PIH）、早产、双胎妊娠和胎儿生长受限（FGR）的发生率。
所有PCOS患者（54.9%；OR：2.9，95%CI：2.0 - 4.1）以及PCOS亚组，无论自然受孕（51.5%；OR：3.3，95%CI：2.0 - 5.4）还是通过体外受精 - 胚胎移植（IVF - ET）或卵巢刺激受孕，GDM的发生率均显著高于对照组（14.3%；P < 0.001）。所有PCOS患者（10.4%；OR：2.2，95%CI：1.1 - 4.4）以及自然受孕亚组（11.8%；OR：2.6，95%CI：1.1 - 6.2；P < 0.001）PIH的发生率也较高，但IVF - ET受孕者（9.1%）或卵巢刺激受孕者（9.4%）并非如此。体重指数（BMI）<24 kg/m²的瘦型PCOS女性GDM（51.1%对14.5%；OR：5.6，95%CI：3.4 - 9.0）和PIH（8.9%对3.2%；OR：3.0，95%CI：1.3 - 7.1）的发生率高于瘦型对照组。糖耐量正常的PCOS女性患PIH的风险高于其相应对照组（OR：4.0，95%CI：1.3 - 11.7）。
本研究表明PCOS是发生GDM和PIH的独立危险因素。本试验已在中国临床试验注册中心注册，注册号为ChiCTR - RCC - 11001824。
