高对映选择性铜催化的丙炔酸酯与 1,3-二羰基化合物的丙炔基取代反应。
Highly enantioselective copper-catalyzed propargylic substitution of propargylic acetates with 1,3-dicarbonyl compounds.
机构信息
College of Chemistry and Chemical Engineering, Qiqihar University , Qiqihar 161006, China.
出版信息
Org Lett. 2014 Jan 17;16(2):588-91. doi: 10.1021/ol403469m. Epub 2013 Dec 27.
PMID:24372393
Abstract
A chiral tridentate ketimine P,N,N-ligand has been successfully applied in the copper-catalyzed enantioselective propargylic substitution of propargylic acetates with a variety of β-dicarbonyl compounds, in which excellent enantioselectivities (up to >99% ee) and high yields have been obtained.
摘要
一种手性三齿酮亚胺 P,N,N-配体已成功应用于铜催化的炔丙基乙酸酯与各种β-二羰基化合物的对映选择性炔丙基取代反应，其中获得了优异的对映选择性（高达>99%ee）和高收率。
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