Zhang Ming, Wang Guang-lin, Zhang Hong-fang, Hu Xu-dong, Shi Xiao-yuan, Li Sen, Lin Wei
Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Artif Organs. 2014 Jun;38(6):493-502. doi: 10.1111/aor.12208. Epub 2013 Dec 23.
A segmental long bone defect in a rabbit radius nonunion model was repaired using cylindrical porous titanium (Ti) and hydroxyapatite (HA) scaffolds. Each scaffold was produced using the same method, namely, a slurry foaming method. Repairing ability was characterized using x-radiographic score 12 and 24 weeks postprocedure; failure load of the radius-ulna construct, under three-point bending, 12 weeks postprocedure; and the percentage of newly formed bone within the implant, 12 and 24 weeks after postprocedure. For each of these parameters, the difference in the results when porous Ti scaffold was used compared with when HA scaffolds were used was not significant; both porous scaffolds showed excellent repairing ability. Because the trabecular bone is a porous tissue, the interconnected porous scaffolds have the advantages of natural bone, and vasculature can grow into the porous structure to accelerate the osteoconduction and osteointegration between the implant and bone. The porous Ti scaffold not only enhanced the bone repair process, similar to porous HA scaffolds, but also has superior biomechanical properties. The present results suggest that porous Ti scaffolds may have promise for use in the clinical setting.
在兔桡骨骨不连模型中，使用圆柱形多孔钛（Ti）和羟基磷灰石（HA）支架修复节段性长骨缺损。每个支架均采用相同的方法制备，即浆料发泡法。通过术后12周和24周的X线评分、术后12周三点弯曲时桡骨 - 尺骨结构的破坏载荷以及术后12周和24周植入物内新形成骨的百分比来表征修复能力。对于这些参数中的每一个，使用多孔Ti支架与使用HA支架时结果的差异均不显著；两种多孔支架均显示出优异的修复能力。由于松质骨是一种多孔组织，相互连通的多孔支架具有天然骨的优势，血管可以长入多孔结构以加速植入物与骨之间的骨传导和骨整合。多孔Ti支架不仅与多孔HA支架类似，增强了骨修复过程，而且具有优异的生物力学性能。目前的结果表明，多孔Ti支架在临床应用中可能具有前景。
