Cho K-D, Paek J, Kang J-H, Chang D, Na K-J, Yang M-P
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
J Vet Intern Med. 2014 Mar-Apr;28(2):429-36. doi: 10.1111/jvim.12270. Epub 2013 Dec 26.
An excess of intra-abdominal fat is observed frequently in dogs with hyperadrenocorticism (HAC). Adipokine dysregulation is a possible cause of complications related to visceral obesity, but little information is available on adipokine in dogs with naturally occurring HAC.
To examine the differences in the circulating adipokines concentrations in overweight dogs with and without pituitary-dependent HAC (PDH).
Thirty healthy dogs and 15 client-owned dogs with PDH.
Case-controlled observational study, which enrolled 15 overweight dogs diagnosed with PDH and 30 otherwise healthy dogs of similar body condition score. Nine of 15 dogs with PDH were treated with low-dose trilostane twice daily and reassessed after treatment.
The serum leptin (P < .0001) and insulin (P < .0001) concentrations were significantly higher in the PDH group (leptin, 22.8 ± 8.8 [mean ± SD]; insulin, 9.1 ± 6.1) than the healthy group (leptin, 4.9 ± 3.7; insulin, 1.9 ± 0.9). However, there were no significant differences in the adiponectin, resistin, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, and IL-18 levels between the 2 groups. In the PDH group, the serum cortisol concentrations had a linear association with the leptin concentrations, and there were significant decreases in the leptin (P = .0039) and insulin (P = .0039) levels after trilostane treatment. However, the leptin and insulin levels remained higher after trilostane treatment than in healthy control dogs with similar body condition score.
Hypercortisolemia in dogs with PDH might upregulate the circulating leptin levels. However, a large population-based study will be necessary to determine whether the upregulation of leptin is involved directly with the complications caused by HAC.
肾上腺皮质功能亢进（HAC）犬常出现腹内脂肪过多的情况。脂肪因子失调可能是内脏肥胖相关并发症的一个原因，但关于自然发生HAC的犬脂肪因子的信息很少。
研究患有和未患有垂体依赖性肾上腺皮质功能亢进（PDH）的超重犬循环脂肪因子浓度的差异。
30只健康犬和15只患PDH的客户拥有犬。
病例对照观察研究，纳入15只诊断为PDH的超重犬和30只身体状况评分相似的健康犬。15只患PDH的犬中有9只每天两次接受低剂量曲洛司坦治疗，并在治疗后重新评估。
PDH组血清瘦素（P <.0001）和胰岛素（P <.0001）浓度显著高于健康组（瘦素，22.8±8.8[平均值±标准差]；胰岛素，9.1±6.1）（瘦素，4.9±3.7；胰岛素，1.9±0.9）。然而，两组之间脂联素、抵抗素、肿瘤坏死因子（TNF）-α、白细胞介素（IL）-1β、IL-6、IL-10和IL-18水平无显著差异。在PDH组中，血清皮质醇浓度与瘦素浓度呈线性相关，曲洛司坦治疗后瘦素（P =.0039）和胰岛素（P =.0039）水平显著降低。然而，曲洛司坦治疗后瘦素和胰岛素水平仍高于身体状况评分相似的健康对照犬。
患PDH犬的高皮质醇血症可能上调循环瘦素水平。然而，需要进行大规模的基于人群的研究来确定瘦素上调是否直接与HAC引起的并发症有关。
