Karottki Dorina Gabriela, Spilak Michal, Frederiksen Marie, Gunnarsen Lars, Brauner Elvira Vaclavik, Kolarik Barbara, Andersen Zorana Jovanovic, Sigsgaard Torben, Barregard Lars, Strandberg Bo, Sallsten Gerd, Møller Peter, Loft Steffen
Section of Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Farimagsgade 5A K, DK-1014 Copenhagen, Denmark.
Environ Health. 2013 Dec 28;12:116. doi: 10.1186/1476-069X-12-116.
Exposure to particulate air pollution increases respiratory and cardiovascular morbidity and mortality, especially in elderly, possibly through inflammation and vascular dysfunction.
We examined potential beneficial effects of indoor air filtration in the homes of elderly, including people taking vasoactive drugs.Forty-eight nonsmoking subjects (51 to 81 years) in 27 homes were included in this randomized, double-blind, crossover intervention study with consecutive two-week periods with or without the inclusion of a high-efficiency particle air filter in re-circulating custom built units in their living room and bedroom. We measured blood pressure, microvascular and lung function and collected blood samples for hematological, inflammation, monocyte surface and lung cell damage markers before and at day 2, 7 and 14 during each exposure scenario.
The particle filters reduced the median concentration of PM2.5 from approximately 8 to 4 μg/m3 and the particle number concentration from 7669 to 5352 particles/cm3. No statistically significant effects of filtration as category were observed on microvascular and lung function or the biomarkers of systemic inflammation among all subjects, or in the subgroups taking (n = 11) or not taking vasoactive drugs (n = 37). However, the filtration efficacy was variable and microvascular function was within 2 days significantly increased with the actual PM2.5 decrease in the bedroom, especially among 25 subjects not taking any drugs.
Substantial exposure contrasts in the bedroom and no confounding by drugs appear required for improved microvascular function by air filtration, whereas no other beneficial effect was found in this elderly population.
暴露于空气中的颗粒物会增加呼吸道和心血管疾病的发病率及死亡率，在老年人中尤其如此，这可能是通过炎症和血管功能障碍导致的。
我们研究了室内空气过滤对老年人家庭（包括正在服用血管活性药物的人）的潜在有益影响。本随机、双盲、交叉干预研究纳入了27户家庭中的48名不吸烟受试者（年龄在51至81岁之间），连续两个为期两周的阶段，在他们客厅和卧室的定制循环装置中，一个阶段包含高效空气过滤器，另一个阶段不包含。在每个暴露阶段开始前以及第2天、第7天和第14天，我们测量了血压、微血管和肺功能，并采集血样以检测血液学、炎症、单核细胞表面和肺细胞损伤标志物。
颗粒过滤器使PM2.5的中位数浓度从约8μg/m³降至4μg/m³，颗粒数浓度从7669个/立方厘米降至5352个/立方厘米。在所有受试者中，或在服用（n = 11）或未服用血管活性药物（n = 37）的亚组中，未观察到过滤作为一个类别对微血管和肺功能或全身炎症生物标志物有统计学上的显著影响。然而，过滤效果存在差异，随着卧室中实际PM2.5的降低，微血管功能在2天内显著增强，尤其是在25名未服用任何药物的受试者中。
卧室中存在显著的暴露差异且无药物干扰似乎是空气过滤改善微血管功能所必需的，而在该老年人群中未发现其他有益效果。
