Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing, China; Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Beijing, China.
Department of Respiratory Medicine, Peking University Third Hospital, Beijing, China.
Sci Total Environ. 2017 Dec 15;603-604:541-549. doi: 10.1016/j.scitotenv.2017.06.095. Epub 2017 Jun 20.
In this Beijing Indoor Air Purifier StudY (BIAPSY), we conducted a randomized crossover intervention trial in a panel of 35 non-smoking senior participants with free-living, with and without chronic obstructive pulmonary disease (COPD). Portable air filtration units were randomly allocated to active-(filter in) for 2weeks and sham-mode (filter out) for 2weeks in the households. We examined the differences in indoor air pollutant concentrations in 20 study homes and a suite of cardio-respiratory biomarker levels in study participants between filtration modes, with and without adjustment for potential confounders. Following active filtration, we observed significant reductions from 60±45 to 24±15μg/m in ten-day averages of indoor PM and reductions from 3.87±1.65 to 1.81±1.19m.10 in ten-day averages of indoor BC, compared to sham-mode filtration. The major components of indoor PM, including water soluble organics, NO, SO, Zn, Pb and K, were also reduced significantly by 42% to 63%. However, following active filtration, we only observed significant reductions on systemic inflammation measured as of IL-8 at 58.59% (95% CI: -76.31, -27.64) in the total group of participants and 70.04% (95% CI: -83.05, -47.05) in the subset of COPD patients, with adjustments. We were not able to detect improvements on lung function, blood pressure, and heart rate variability, following short-term intervention of two-week active air filtration. In conclusion, our results showed that indoor air filtration produced clear improvement on indoor air quality, but no demonstrable changes in the cardio-respiratory outcomes of study interest observed in the seniors living with real-world air pollution exposures.
在这项北京室内空气净化器研究（BIAPSY）中，我们在一个由 35 名不吸烟的老年人组成的小组中进行了一项随机交叉干预试验，这些老年人有自由生活的环境，患有或不患有慢性阻塞性肺疾病（COPD）。便携式空气过滤装置随机分配到主动模式（过滤器开启）2 周和假模式（过滤器关闭）2 周，在家庭中使用。我们在 20 个研究家庭中检测了过滤模式之间室内空气污染物浓度的差异，并在调整潜在混杂因素后，检测了研究参与者的一系列心肺生物标志物水平的差异。在主动过滤后，我们观察到室内 PM 的 10 天平均值从 60±45μg/m3 降至 24±15μg/m3，室内 BC 的 10 天平均值从 3.87±1.65m3降至 1.81±1.19m3，与假模式过滤相比。室内 PM 的主要成分，包括水溶性有机物、NO、SO、Zn、Pb 和 K，也分别减少了 42%至 63%。然而，在主动过滤后，我们仅观察到总组参与者的白细胞介素 8（IL-8）的全身炎症标志物有显著降低，降幅为 58.59%（95%可信区间：-76.31，-27.64），在 COPD 患者亚组中，降幅为 70.04%（95%可信区间：-83.05，-47.05），这些都经过了调整。我们未能检测到短期两周主动空气过滤干预后肺功能、血压和心率变异性的改善。总之，我们的研究结果表明，室内空气过滤明显改善了室内空气质量，但在现实世界空气污染暴露环境下，对老年人的心肺研究结果没有明显改善。
