Freire de Melo Fabrício, Rocha Gifone Aguiar, Rocha Andreia Maria Camargos, Teixeira Kádima Nayara, Pedroso Silvia Helena Souza Pietra, Pereira Junior João Bosco, Fonseca de Castro Lúcia Porto, Cabral Mônica Maria Demas Álvares, Carvalho Simone Diniz, Bittencourt Paulo Fernando Souto, de Oliveira Celso Afonso, Queiroz Dulciene Maria de Magalhães
Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Departament of Microbiology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Int J Med Microbiol. 2014 May;304(3-4):300-6. doi: 10.1016/j.ijmm.2013.11.001. Epub 2013 Nov 9.
To compare children and adults in respect to the effect of H. pylori infection on the gastric concentrations of cytokines linked to innate and Th1 immune response, as well as to investigate the changes in the gastric concentrations of the studied cytokines according to the age. We studied 245 children (142 H. pylori-negative and 103 H. pylori-positive) and 140 adults (40 H. pylori-negative and 100 H. pylori-positive). The gastric concentrations of cytokines representative of the innate and Th1 response were higher in the H. pylori-positive than in the -negative children and adults. The gastric concentrations of IL-1α and TNF-α were significantly higher, while those of IL-2, IL-12p70 and IFN-γ were lower in the infected children than in the infected adults. In the infected children, the gastric concentration of IL-1α, IL-2, IL-12p70 and IFN-γ increased, whereas in adults, the gastric concentrations of IFN-γ and IL-12p70 decreased with the aging. Increased gastric concentration of Th1 associated cytokines correlated with increased degree of gastritis that is the background lesion for the development of the H. pylori associated severe diseases. Concluding, Th1 response to H. pylori infection varies according to the age and seems to have determinant implication in the H. pylori infection outcomes.
比较儿童和成人幽门螺杆菌感染对与固有免疫和Th1免疫反应相关的胃内细胞因子浓度的影响，并根据年龄研究所研究细胞因子的胃内浓度变化。我们研究了245名儿童（142名幽门螺杆菌阴性和103名幽门螺杆菌阳性）和140名成人（40名幽门螺杆菌阴性和100名幽门螺杆菌阳性）。幽门螺杆菌阳性的儿童和成人中，代表固有免疫和Th1反应的细胞因子的胃内浓度高于阴性者。感染儿童中IL-1α和TNF-α的胃内浓度显著更高，而IL-2、IL-12p70和IFN-γ的胃内浓度低于感染成人。在感染儿童中，IL-1α、IL-2、IL-12p70和IFN-γ的胃内浓度升高，而在成人中，IFN-γ和IL-12p70的胃内浓度随年龄增长而降低。Th1相关细胞因子胃内浓度的增加与胃炎程度的增加相关，胃炎是幽门螺杆菌相关严重疾病发生的背景病变。结论是，对幽门螺杆菌感染的Th1反应因年龄而异，似乎对幽门螺杆菌感染结果具有决定性影响。
