Patel Chirag J, Yang Ting, Hu Zhongkai, Wen Qiaojun, Sung Joyce, El-Sayed Yasser Y, Cohen Harvey, Gould Jeffrey, Stevenson David K, Shaw Gary M, Ling Xuefeng Bruce, Butte Atul J
Center for Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Reprod Toxicol. 2014 Jun;45:1-7. doi: 10.1016/j.reprotox.2013.12.005. Epub 2013 Dec 27.
Identification of maternal environmental factors influencing preterm birth risks is important to understand the reasons for the increase in prematurity since 1990. Here, we utilized a health survey, the US National Health and Nutrition Examination Survey (NHANES) to search for personal environmental factors associated with preterm birth. 201 urine and blood markers of environmental factors, such as allergens, pollutants, and nutrients were assayed in mothers (range of N: 49-724) who answered questions about any children born preterm (delivery <37 weeks). We screened each of the 201 factors for association with any child born preterm adjusting by age, race/ethnicity, education, and household income. We attempted to verify the top finding, urinary bisphenol A, in an independent study of pregnant women attending Lucile Packard Children's Hospital. We conclude that the association between maternal urinary levels of bisphenol A and preterm birth should be evaluated in a larger epidemiological investigation.
识别影响早产风险的母体环境因素对于理解自1990年以来早产率上升的原因至关重要。在此，我们利用一项健康调查，即美国国家健康与营养检查调查（NHANES）来寻找与早产相关的个人环境因素。在回答了有关任何早产（分娩孕周<37周）子女问题的母亲中（样本量范围为49 - 724），检测了201种环境因素的尿液和血液标志物，如过敏原、污染物和营养素。我们对这201种因素中的每一种都进行了筛查，以确定其与任何早产子女之间的关联，并对年龄、种族/族裔、教育程度和家庭收入进行了调整。我们试图在一项针对卢西尔·帕卡德儿童医院就诊孕妇的独立研究中验证首要发现——尿中双酚A。我们得出结论，应在更大规模的流行病学调查中评估母体尿中双酚A水平与早产之间的关联。
