Li Tao, Yin Danyang, Shi Rengfei
School of Health and Exercise, Shanghai University of Sport, Shanghai, China.
Front Nutr. 2024 Aug 16;11:1418778. doi: 10.3389/fnut.2024.1418778. eCollection 2024.
Sarcopenia refers to an age-related systemic skeletal muscle disorder, which is characterized by loss of muscle mass and weakening of muscle strength. Gut microbiota can affect skeletal muscle through a variety of mechanisms. Gut microbiota present distinct features among elderly people and sarcopenia patients, including a decrease in microbial diversity, which might be associated with the quality and function of the skeletal muscle. There might be a gut-muscle axis; where gut microbiota and skeletal muscle may affect each other bi-directionally. Skeletal muscle can affect the biodiversity of the gut microbiota, and the latter can, in turn, affect the anabolism of skeletal muscle. This review examines recent studies exploring the relationship between gut microbiota and skeletal muscle, summarizes the effects of exercise on gut microbiota, and discusses the possible mechanisms of the gut-muscle axis.
肌肉减少症是一种与年龄相关的全身性骨骼肌疾病，其特征是肌肉质量丧失和肌肉力量减弱。肠道微生物群可通过多种机制影响骨骼肌。老年人和肌肉减少症患者的肠道微生物群具有不同特征，包括微生物多样性降低，这可能与骨骼肌的质量和功能有关。可能存在肠-肌轴，即肠道微生物群和骨骼肌可能双向相互影响。骨骼肌可影响肠道微生物群的生物多样性，而后者反过来又可影响骨骼肌的合成代谢。本综述探讨了探索肠道微生物群与骨骼肌之间关系的最新研究，总结了运动对肠道微生物群的影响，并讨论了肠-肌轴的可能机制。
