Department of General Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Department of Respiratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
FEBS Lett. 2014 Feb 14;588(4):538-44. doi: 10.1016/j.febslet.2013.12.009. Epub 2013 Dec 25.
MicroRNA-107 (miR-107) has been demonstrated to regulate proliferation and apoptosis in many types of cancers. Nevertheless, its biological function in gastric cancer remains largely unexplored. Here, we found that the expression level of miR-107 was increased in gastric cancer in comparison with the adjacent normal tissues. The enforced expression of miR-107 was able to promote cell proliferation in NCI-N87 and AGS cells, while miR-107 antisense oligonucleotides (antisense miR-107) blocked cell proliferation. At the molecular level, our results further revealed that expression of FOXO1 was negatively regulated by miR-107. Therefore, the data reported here demonstrate that miR-107 is an important regulator in gastric cancer, which will contribute to a better understanding of the important mis-regulated miRNAs in gastric cancer.
MicroRNA-107 (miR-107) 已被证明在多种类型的癌症中调节增殖和凋亡。然而，其在胃癌中的生物学功能在很大程度上仍未被探索。在这里，我们发现与相邻的正常组织相比，胃癌中 miR-107 的表达水平升高。miR-107 的强制表达能够促进 NCI-N87 和 AGS 细胞的增殖，而 miR-107 反义寡核苷酸（反义 miR-107）则阻止细胞增殖。在分子水平上，我们的结果进一步表明 FOXO1 的表达受 miR-107 负调控。因此，这里报道的数据表明 miR-107 是胃癌的一个重要调节因子，这将有助于更好地理解胃癌中重要失调的 miRNA。
