Li Yiwei, Ahmad Aamir, Kong Dejuan, Bao Bin, Sarkar Fazlul H
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 740 Hudson Webber Cancer Research Center, 4100 John R, Detroit, MI, 48201, USA.
Cancer Metastasis Rev. 2014 Sep;33(2-3):629-40. doi: 10.1007/s10555-013-9478-9.
Recently, nutraceuticals have received increasing attention as the agents for cancer prevention and supplement with conventional therapy. Prostate cancer (PCa) is the most frequently diagnosed cancer and second leading cause of cancer-related death in men in the US. Growing evidences from epidemiological studies, in vitro experimental studies, animal studies, and clinical trials have shown that nutraceuticals could be very useful for the prevention and treatment of PCa. Several nutraceuticals including isoflavone, indole-3-carbinol, 3,3'-diindolylmethane, lycopene, (-)-epigallocatechin-3-gallate, and curcumin are known to downregulate the signal transductions in AR, Akt, NF-κB, and other signal transduction pathways which are vital for the development of PCa and the progression of PCa from androgen-sensitive to castrate-resistant PCa. Therefore, nutraceutical treatment in combination with conventional therapeutics could achieve better treatment outcome in prostate cancer therapy. Interestingly, some nutraceuticals could regulate the function of cancer stem cell (CSC)-related miRNAs and associated molecules, leading to the inhibition of prostatic CSCs which are responsible for drug resistance, tumor progression, and recurrence of PCa. Hence, nutraceuticals may serve as powerful agents for the prevention of PCa progression and they could also be useful in combination with chemotherapeutics or radiotherapy. Such strategy could become a promising newer approach for the treatment of metastatic PCa with better treatment outcome by improving overall survival.
近年来，营养保健品作为癌症预防和辅助传统治疗的药物受到越来越多的关注。前列腺癌（PCa）是美国男性中最常被诊断出的癌症，也是癌症相关死亡的第二大原因。来自流行病学研究、体外实验研究、动物研究和临床试验的越来越多的证据表明，营养保健品对前列腺癌的预防和治疗可能非常有用。已知包括异黄酮、吲哚 - 3 - 甲醇、3,3'-二吲哚甲烷、番茄红素、（-）-表没食子儿茶素 - 3 - 没食子酸酯和姜黄素在内的几种营养保健品可下调AR、Akt、NF - κB以及其他对前列腺癌的发生和从雄激素敏感型前列腺癌发展为去势抵抗型前列腺癌至关重要的信号转导途径中的信号转导。因此，营养保健品与传统疗法联合治疗在前列腺癌治疗中可取得更好的治疗效果。有趣的是，一些营养保健品可调节癌症干细胞（CSC）相关miRNA和相关分子的功能，从而抑制负责前列腺癌耐药性、肿瘤进展和复发的前列腺CSC。因此，营养保健品可能是预防前列腺癌进展有力的药物，它们与化疗或放疗联合使用也可能有用。这种策略可能成为一种有前景的新方法，通过提高总生存率来更好地治疗转移性前列腺癌。
