Adana Numune Training and Research Hospital, Department of Cardiology, Adana, Turkey.
J Clin Lab Anal. 2014 Jan;28(1):52-8. doi: 10.1002/jcla.21643. Epub 2013 Dec 27.
There are limited number of studies about relationship between serum vitamin D level and presence and severity of coronary artery disease (CAD). We assessed the relationship between the extent and complexity of CAD assessed by SYNTAX score and 25-hydroxyvitamin D level in patients with stable CAD.
In the study, 209 consecutive patients with stable CAD (age: 63.1 ± 10.0 years) and 102 healthy control subjects (age 61.3 ± 13.7 years) were included. Serum 25-hydroxyvitamin D was measured using a direct competitive chemiluminescent immunoassay and other biochemical markers were measured in all subjects. All subjects underwent coronary angiography and SS was calculated.
The mean serum 25-hydroxyvitamin D level of CAD group was lower than the control group (P < 0,001). Multivariate regression analysis showed that serum 25-hydroxyvitamin D level was independently associated with SYNTAX score (β = -0.396, P < 0.001), hypertension (β = -0.183, P = 0.003), high sensitive C-reactive protein (β = -0.141, P = 0.014), and body mass index (β = -0.135, P = 0.023) in patient group.
25-Hydroxyvitamin D level was associated with extent and complexity of CAD. 25-Hydroxyvitamin D may play a role in pathogenesis and severity of coronary atherosclerosis.
关于血清维生素 D 水平与冠状动脉疾病（CAD）的存在和严重程度之间的关系，研究数量有限。我们评估了通过 SYNTAX 评分评估的 CAD 的程度和复杂性与稳定型 CAD 患者的 25-羟维生素 D 水平之间的关系。
在这项研究中，纳入了 209 例连续的稳定型 CAD 患者（年龄：63.1 ± 10.0 岁）和 102 例健康对照者（年龄 61.3 ± 13.7 岁）。使用直接竞争化学发光免疫分析法测定血清 25-羟维生素 D，所有受试者均测定其他生化标志物。所有受试者均接受冠状动脉造影检查，计算 SS。
CAD 组的平均血清 25-羟维生素 D 水平低于对照组（P < 0.001）。多变量回归分析表明，血清 25-羟维生素 D 水平与 SYNTAX 评分独立相关（β = -0.396，P < 0.001）、与高血压（β = -0.183，P = 0.003）、高敏 C 反应蛋白（β = -0.141，P = 0.014）和体重指数（β = -0.135，P = 0.023）相关。
25-羟维生素 D 水平与 CAD 的程度和复杂性相关。25-羟维生素 D 可能在冠状动脉粥样硬化的发病机制和严重程度中发挥作用。
