各种方式——棘皮动物中的nanos基因调控
Every which way--nanos gene regulation in echinoderms.
作者信息
Oulhen Nathalie, Wessel Gary M
机构信息
Department of Molecular and Cell Biology and Biochemistry, Brown University, Providence, Rhode Island.
出版信息
Genesis. 2014 Mar;52(3):279-86. doi: 10.1002/dvg.22737. Epub 2014 Jan 17.
Abstract
Nanos is an essential factor of germ line success in all animals tested. This gene encodes a Zn-finger RNA-binding protein that in complex with its partner pumilio binds to and changes the fate of several known transcripts. We summarize here the documented functions of Nanos in several key organisms, and then emphasize echinoderms as a working model for how nanos expression is regulated. Nanos presence outside of the target cells is often detrimental to the animal, and in sea urchins, nanos expression appears to be regulated at every step of transcription, and post-transcriptional activity, making this gene product exciting, every which way.
摘要
在所有已测试的动物中，Nanos是生殖系成功发育的关键因素。该基因编码一种锌指RNA结合蛋白，它与其伴侣Pumilio形成复合物，结合并改变几种已知转录本的命运。我们在此总结了Nanos在几种关键生物中的已记录功能，然后着重介绍棘皮动物，将其作为研究Nanos表达调控的一个工作模型。Nanos在靶细胞外的存在通常对动物有害，在海胆中，Nanos的表达似乎在转录和转录后活动的每个步骤都受到调控，这使得这种基因产物在各个方面都令人兴奋。
相似文献
1
Every which way--nanos gene regulation in echinoderms.各种方式——棘皮动物中的nanos基因调控
Genesis. 2014 Mar;52(3):279-86. doi: 10.1002/dvg.22737. Epub 2014 Jan 17.
2
Differential Nanos 2 protein stability results in selective germ cell accumulation in the sea urchin.差异纳米2蛋白稳定性导致海胆中生殖细胞的选择性积累。
Dev Biol. 2016 Oct 1;418(1):146-156. doi: 10.1016/j.ydbio.2016.07.007. Epub 2016 Jul 14.
3
Post-transcriptional regulation of factors important for the germ line.对生殖系重要的因子的转录后调控。
Curr Top Dev Biol. 2022;146:49-78. doi: 10.1016/bs.ctdb.2021.10.003. Epub 2021 Dec 3.
4
The diversity of nanos expression in echinoderm embryos supports different mechanisms in germ cell specification.棘皮动物胚胎中nanos表达的多样性支持生殖细胞特化的不同机制。
Evol Dev. 2016 Jul;18(4):267-78. doi: 10.1111/ede.12197.
5
Functional annotation of a hugely expanded nanos repertoire in Lytechinus variegatus, the green sea urchin.在绿海胆（Lytechinus variegatus）中，大量扩展的 Nanos 基因家族的功能注释。
Mol Reprod Dev. 2023 May;90(5):310-322. doi: 10.1002/mrd.23684. Epub 2023 Apr 11.
6
Nanos suppresses somatic cell fate in Drosophila germ line.Nanos抑制果蝇生殖系中的体细胞命运。
Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10338-42. doi: 10.1073/pnas.0401647101. Epub 2004 Jul 6.
7
Nanos and Pumilio have critical roles in the development and function of Drosophila germline stem cells.纳诺斯（Nanos）和普米利奥（Pumilio）在果蝇生殖系干细胞的发育和功能中起着关键作用。
Development. 1998 Feb;125(4):679-90. doi: 10.1242/dev.125.4.679.
8
Sex-lethal enables germline stem cell differentiation by down-regulating Nanos protein levels during Drosophila oogenesis.性别致死通过下调果蝇卵子发生过程中的 Nanos 蛋白水平来促进生殖干细胞分化。
Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9465-70. doi: 10.1073/pnas.1120473109. Epub 2012 May 29.
9
Maternal Nanos-Dependent RNA Stabilization in the Primordial Germ Cells of Drosophila Embryos.果蝇胚胎原始生殖细胞中母源性 Nanos 依赖的 RNA 稳定化。
Dev Growth Differ. 2018 Jan;60(1):63-75. doi: 10.1111/dgd.12414. Epub 2017 Dec 26.
10
Distinct transcriptional regulation of Nanos2 in the germ line and soma by the Wnt and delta/notch pathways.Wnt 和 delta/notch 通路对生殖细胞和体细胞中线粒体 2 的转录调控作用不同。
Dev Biol. 2019 Aug 1;452(1):34-42. doi: 10.1016/j.ydbio.2019.04.010. Epub 2019 May 7.
引用本文的文献
1
Comparative Analysis of and Genes Expression in the Germinative Cells Isolated from Germinal Layer and the Neck Region of .从生发层和[具体生物名称]颈部区域分离的生殖细胞中[具体基因名称1]和[具体基因名称2]基因表达的比较分析 。
需注意，原文中“and”前后的具体基因名称缺失，我按格式要求原样翻译了，你可补充完整准确信息后再让我翻译。
Iran J Parasitol. 2024 Apr-Jun;19(2):131-139. doi: 10.18502/ijpa.v19i2.15849.
2
Me31B: a key repressor in germline regulation and beyond.Me31B：生殖系调控及其他方面的关键抑制因子。
Biosci Rep. 2024 May 29;44(5). doi: 10.1042/BSR20231769.
3
Functional annotation of a hugely expanded nanos repertoire in Lytechinus variegatus, the green sea urchin.在绿海胆（Lytechinus variegatus）中，大量扩展的 Nanos 基因家族的功能注释。
Mol Reprod Dev. 2023 May;90(5):310-322. doi: 10.1002/mrd.23684. Epub 2023 Apr 11.
4
Elements of divergence in germline determination in closely related species.近缘物种中生殖系决定的差异因素。
iScience. 2023 Mar 15;26(4):106402. doi: 10.1016/j.isci.2023.106402. eCollection 2023 Apr 21.
5
CRISPR-Cas9 editing of non-coding genomic loci as a means of controlling gene expression in the sea urchin.作为一种控制海胆基因表达的手段，对非编码基因组位点进行CRISPR-Cas9编辑。
Dev Biol. 2021 Apr;472:85-97. doi: 10.1016/j.ydbio.2021.01.003. Epub 2021 Jan 19.
6
Maternal Nanos inhibits Importin-α2/Pendulin-dependent nuclear import to prevent somatic gene expression in the Drosophila germline.母源 Nanos 通过抑制 Importin-α2/Pendulin 依赖性核输入，防止果蝇生殖细胞中体细胞基因的表达。
PLoS Genet. 2019 May 15;15(5):e1008090. doi: 10.1371/journal.pgen.1008090. eCollection 2019 May.
7
Distinct transcriptional regulation of Nanos2 in the germ line and soma by the Wnt and delta/notch pathways.Wnt 和 delta/notch 通路对生殖细胞和体细胞中线粒体 2 的转录调控作用不同。
Dev Biol. 2019 Aug 1;452(1):34-42. doi: 10.1016/j.ydbio.2019.04.010. Epub 2019 May 7.
8
Function of Nanos1 gene in the development of reproductive organs of Schistosoma japonicum.日本血吸虫Nanos1基因在生殖器官发育中的作用
Parasitol Res. 2017 May;116(5):1505-1513. doi: 10.1007/s00436-017-5427-9. Epub 2017 Mar 28.
9
Differential Nanos 2 protein stability results in selective germ cell accumulation in the sea urchin.差异纳米2蛋白稳定性导致海胆中生殖细胞的选择性积累。
Dev Biol. 2016 Oct 1;418(1):146-156. doi: 10.1016/j.ydbio.2016.07.007. Epub 2016 Jul 14.
10
Cyclin B Translation Depends on mTOR Activity after Fertilization in Sea Urchin Embryos.海胆胚胎受精后细胞周期蛋白B的翻译依赖于mTOR活性。
PLoS One. 2016 Mar 10;11(3):e0150318. doi: 10.1371/journal.pone.0150318. eCollection 2016.
本文引用的文献
1
A NANOS3 mutation linked to protein degradation causes premature ovarian insufficiency.一种与蛋白质降解相关的 NANOS3 突变导致卵巢早衰。
Cell Death Dis. 2013 Oct 3;4(10):e825. doi: 10.1038/cddis.2013.368.
2
Selective accumulation of germ-line associated gene products in early development of the sea star and distinct differences from germ-line development in the sea urchin.海星早期发育过程中生殖系相关基因产物的选择性积累以及与海胆生殖系发育的明显差异。
Dev Dyn. 2014 Apr;243(4):568-87. doi: 10.1002/dvdy.24038. Epub 2013 Dec 25.
3
Repressive translational control in germ cells.生殖细胞中的抑制性翻译调控。
Mol Reprod Dev. 2013 Aug;80(8):665-76. doi: 10.1002/mrd.22161. Epub 2013 Mar 18.
4
The 3'UTR of nanos2 directs enrichment in the germ cell lineage of the sea urchin.nanos2 的 3'UTR 指导海胆生殖细胞系的富集。
Dev Biol. 2013 May 1;377(1):275-83. doi: 10.1016/j.ydbio.2013.01.019. Epub 2013 Jan 25.
5
nanos3 maintains germline stem cells and expression of the conserved germline stem cell gene nanos2 in the zebrafish ovary.nanos3 维持生殖干细胞，并在斑马鱼卵巢中表达保守的生殖干细胞基因 nanos2。
Dev Biol. 2013 Feb 15;374(2):308-18. doi: 10.1016/j.ydbio.2012.12.003. Epub 2012 Dec 7.
6
Autonomy in specification of primordial germ cells and their passive translocation in the sea urchin.原生殖细胞的自主性及其在海胆中的被动迁移。
Development. 2012 Oct;139(20):3786-94. doi: 10.1242/dev.082230.
7
The forkhead transcription factor FoxY regulates Nanos.叉头转录因子 FoxY 调控 Nanos。
Mol Reprod Dev. 2012 Oct;79(10):680-8. doi: 10.1002/mrd.22073. Epub 2012 Aug 15.
8
Xenopus Nanos1 is required to prevent endoderm gene expression and apoptosis in primordial germ cells.非洲爪蟾 Nanos1 对于原始生殖细胞中内胚层基因表达和凋亡的抑制是必需的。
Development. 2012 Apr;139(8):1476-86. doi: 10.1242/dev.079608. Epub 2012 Mar 7.
9
NANOS3 function in human germ cell development.NANOS3 在人类生殖细胞发育中的作用。
Hum Mol Genet. 2011 Jun 1;20(11):2238-50. doi: 10.1093/hmg/ddr114. Epub 2011 Mar 19.
10
Xenopus germline nanos1 is translationally repressed by a novel structure-based mechanism.非洲爪蟾生殖系 nanos1 通过一种新的基于结构的机制被翻译抑制。
Development. 2011 Feb;138(3):589-98. doi: 10.1242/dev.056705.
Zotero 插件