Department of Dermatology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China.
Department of Preventive Dentistry, Shanghai Stomatological Disease Center, Shanghai 200001, China.
Mediators Inflamm. 2013;2013:801974. doi: 10.1155/2013/801974. Epub 2013 Nov 26.
Interleukin- (IL-) 22 is the signature cytokine of T-helper (Th) 22 cells, and IL-23 is required for IL-22 production. The objective of this study was to examine the immunoexpression of IL-22 and IL-23 in archival paraffin-embedded biopsy specimens from oral LP (n = 42) and cutaneous LP (n = 38) against normal control tissues. The results showed that the percentage of cells expressing IL-22 and IL-23 in LP were significantly higher in LP compared to controls, respectively (both P < 0.001). The correlation between IL-22 and IL-23 expression was significant (P < 0.05). Moreover, the percentage of cells expressing IL-22 and IL-23 in oral LP were significantly higher than cutaneous LP (P < 0.05). Collectively, our findings demonstrated that the increased expression of IL-22 and IL-23 in LP lesions could play roles in the pathogenesis of LP. Moreover, oral LP expressing IL-22 and IL-23 was higher than cutaneous LP, probably due to Th22 cells as an important component of oral mucosal host defense against oral microbiota and tissue antigens. This may be associated with the difference in clinical behaviour of the two variants of the disease.
白细胞介素- (IL-) 22 是辅助性 T 细胞 (Th) 22 细胞的特征性细胞因子，而 IL-23 则是 IL-22 产生所必需的。本研究旨在检测白细胞介素-22 (IL-22) 和白细胞介素-23 (IL-23) 在口腔 LP (n = 42) 和皮肤 LP (n = 38) 存档石蜡包埋活检标本中的免疫表达情况，并与正常对照组织进行比较。结果表明，LP 中表达 IL-22 和 IL-23 的细胞百分比明显高于对照组 (均 P < 0.001)。IL-22 和 IL-23 表达之间存在显著相关性 (P < 0.05)。此外，口腔 LP 中表达 IL-22 和 IL-23 的细胞百分比明显高于皮肤 LP (P < 0.05)。综上所述，我们的研究结果表明，LP 病变中 IL-22 和 IL-23 的表达增加可能在 LP 的发病机制中起作用。此外，口腔 LP 表达的 IL-22 和 IL-23 高于皮肤 LP，可能是由于 Th22 细胞作为口腔黏膜防御口腔微生物群和组织抗原的重要组成部分。这可能与疾病两种变异型的临床行为差异有关。
