Patsatsi A, Kyriakou A, Karavasilis V, Panteliadou K, Sotiriadis D
2 Dermatology Department.
Department of Medical Oncology, Medical School, Aristotle University, Papageorgiou Hospital, Thessaloniki, Greece.
Hippokratia. 2013 Apr;17(2):174-6.
Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBL-LT) is a primary cutaneous B-cell lymphoma of intermediate behavior. The disease predominantly affects elderly patients. A 76-year old man presented with red to violaceous nodules in the anterior aspect of both tibias. Histology confirmed the diagnosis of PCDLBL-LT. A thorough clinical and laboratory investigation was negative for any systemic involvement. However, computed tomography of the thorax showed mediastinal lymphadenopathy. Both bone marrow aspiration and trephine did not show any evidence of bone marrow infiltration. Initially R-CHOP regimen (rituximab-cyclophosphamide, doxorubicin, vincristine, prednisone) achieved a total clearance of the lesions. Nevertheless, five months later patient presented with a relapse and was managed with palliative radiotherapy. The same treatment modality was applied for the second recurrence, as well. PCDLBL-LT affects mostly elderly patients. The consequent age related comorbidities and the frequent relapses require a strict follow up of the patients.
原发性皮肤弥漫性大B细胞淋巴瘤，腿部型（PCDLBL-LT）是一种具有中等侵袭性的原发性皮肤B细胞淋巴瘤。该疾病主要影响老年患者。一名76岁男性双侧胫骨前部出现从红色到紫罗兰色的结节。组织学检查确诊为PCDLBL-LT。全面的临床和实验室检查未发现任何系统性受累迹象。然而，胸部计算机断层扫描显示纵隔淋巴结肿大。骨髓穿刺和活检均未发现骨髓浸润的证据。最初采用R-CHOP方案（利妥昔单抗-环磷酰胺、阿霉素、长春新碱、泼尼松）使病变完全消退。然而，五个月后患者复发，接受了姑息性放疗。第二次复发时也采用了相同的治疗方式。PCDLBL-LT主要影响老年患者。随之而来的与年龄相关的合并症以及频繁复发需要对患者进行严格随访。
