1 Department of High Altitude Military Hygiene, College of High Altitude Military Medicine, Third Military Medical University , Chongqing, China .
High Alt Med Biol. 2013 Dec;14(4):338-41. doi: 10.1089/ham.2012.1091.
Examined the change in neurobehavioral function of individuals acclimated to high altitudes and those native to high altitudes.
A neurobehavioral core test battery approved by the WHO (WHO-NCTB) was used to evaluate the effects of high altitude hypoxia on neurobehavioral function. The WHO-NCTB is composed of seven individual tests: a mood state profile, simple reaction time test, digit span test, Santa Ana manual dexterity test, digit symbol test, Benton visual retention test, and pursuit aiming test.
The values from the Santa Ana manual dexterity test, digit symbol test, and pursuit aiming test from sea-level subjects acclimated for 5 days at 3700 m were significantly decreased when compared with the same subjects at sea level. The values from the digit span, Santa Ana manual dexterity, digit symbol, Benton visual retention and pursuit aiming tests in subjects native to high altitudes of 3700, 4500, and 5100 m were significantly decreased when compared with subjects at sea level and compared with sea-level subjects acclimated for 5 days at 3700 m.
These results demonstrate that high altitude hypoxia induces damage to neurobehavioral functions, and the long-term deficit in neurobehavioral function was more severe than the short-term changes.
研究高原习服者和高原世居者的神经行为功能变化。
采用世界卫生组织（WHO）神经行为核心测试组合（WHO-NCTB）评估高原低氧对神经行为功能的影响。WHO-NCTB 由七个单项测试组成：心境状态量表、简单反应时测试、数字跨度测试、圣安娜手灵巧测试、数字符号测试、本顿视觉保持测试和追踪瞄准测试。
与海平面相比，在海拔 3700 米处适应 5 天的海平面受试者的圣安娜手灵巧测试、数字符号测试和追踪瞄准测试值显著降低。来自海拔 3700 米、4500 米和 5100 米的高原世居者的数字跨度、圣安娜手灵巧、数字符号、本顿视觉保持和追踪瞄准测试值与海平面受试者和在海拔 3700 米处适应 5 天的海平面受试者相比显著降低。
这些结果表明，高原低氧会导致神经行为功能受损，且长期的神经行为功能缺陷比短期变化更为严重。
