Prabhu Venugopal Vinod, Sakthivel Kunnathur Murugesan, Guruvayoorappan Chandrasekharan
Department of Biotechnology, Karunya University, Tamil Nadu, India E-mail :
Asian Pac J Cancer Prev. 2013;14(11):6215-20. doi: 10.7314/apjcp.2013.14.11.6215.
Kisspeptins (KPs) encoded by the KiSS-1 gene are C-terminally amidated peptide products, including KP- 10, KP-13, KP-14 and KP-54, which are endogenous agonists for the G-protein coupled receptor-54 (GPR54). Functional analyses have demonstrated fundamental roles of KiSS-1 in whole body homeostasis including sexual differentiation of brain, action on sex steroids and metabolic regulation of fertility essential for human puberty and maintenance of adult reproduction. In addition, intensive recent investigations have provided substantial evidence suggesting roles of Kisspeptin signalling via its receptor GPR54 in the suppression of metastasis with a variety of cancers. The present review highlights the latest studies regarding the role of Kisspeptins and the KiSS-1 gene in tumor progression and also suggests targeting the KiSS-1/GPR54 system may represent a novel therapeutic approach for cancers. Further investigations are essential to elucidate the complex pathways regulated by the Kisspeptins and how these pathways might be involved in the suppression of metastasis across a range of cancers.
由KiSS-1基因编码的亲吻素（KPs）是C末端酰胺化的肽产物，包括KP-10、KP-13、KP-14和KP-54，它们是G蛋白偶联受体54（GPR54）的内源性激动剂。功能分析表明，KiSS-1在全身稳态中发挥着重要作用，包括大脑的性别分化、对性类固醇的作用以及对人类青春期和成年生殖维持至关重要的生育能力的代谢调节。此外，最近的深入研究提供了大量证据，表明亲吻素通过其受体GPR54发出的信号在多种癌症的转移抑制中发挥作用。本综述重点介绍了关于亲吻素和KiSS-1基因在肿瘤进展中的作用的最新研究，并表明靶向KiSS-1/GPR54系统可能代表一种针对癌症的新型治疗方法。进一步的研究对于阐明亲吻素调节的复杂途径以及这些途径如何参与一系列癌症的转移抑制至关重要。
