Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, Wales CF14 4XN, UK.
Int J Mol Med. 2013 Oct;32(4):747-54. doi: 10.3892/ijmm.2013.1472. Epub 2013 Aug 21.
Metastasis is a complex multistep process that involves the impairment of cell-cell adhesion in the neoplastic epithelium, invasion into adjacent tissues and the dissemination of cancer cells through the lymphatic and haematogenous routes. The inhibition of the metastatic process at an early stage has become a hot topic in cancer research. The Kiss-1 gene, initially described as a suppressor of metastasis in malignant melanoma, encodes the Kiss-1 protein which can be processed to other peptides, e.g., Kisspeptin-10, Kisspeptin-13, Kisspeptin-14 and Kisspeptin-54. These peptides are endogenous ligands of the Kiss‑1 receptor (Kiss-1R), a G protein-coupled receptor (GPR) also known as hOT7T175, AXOR12 or GPR54. The Kiss-1 gene has been suggested as a suppressor of metastasis in a various types of cancer, including gastric cancer, oesophageal carcinoma, pancreatic, ovarian, bladder and prostate cancer, through the regulation of cellular migration and invasion. In the current review, we summarise the current understanding of the role of Kiss‑1 and Kiss‑1R in cancer and cancer metastasis.
转移是一个复杂的多步骤过程，涉及肿瘤上皮细胞间黏附的破坏、浸润到邻近组织以及癌细胞通过淋巴和血行途径的扩散。在早期抑制转移过程已成为癌症研究的一个热点。Kiss-1 基因最初被描述为恶性黑色素瘤转移的抑制基因，其编码的 Kiss-1 蛋白可被加工成其他肽，如 Kisspeptin-10、Kisspeptin-13、Kisspeptin-14 和 Kisspeptin-54。这些肽是 Kiss-1 受体（Kiss-1R）的内源性配体，Kiss-1R 是一种 G 蛋白偶联受体（GPR），也称为 hOT7T175、AXOR12 或 GPR54。通过调节细胞迁移和侵袭，Kiss-1 基因已被认为是多种癌症（包括胃癌、食管癌、胰腺癌、卵巢癌、膀胱癌和前列腺癌）转移的抑制基因。在本综述中，我们总结了目前对 Kiss-1 和 Kiss-1R 在癌症和癌症转移中的作用的认识。
