Budak Adnan, Gulhan Ibrahim, Aldemir Onur Suleyman, Ileri Alper, Tekin Emine, Ozeren Mehmet
Tepecik Education and Research Hospital, Department of Gynecology and Obstetrics, Izmir, Turkey E-mail :
Asian Pac J Cancer Prev. 2013;14(11):6941-3. doi: 10.7314/apjcp.2013.14.11.6941.
The aim of this study is to investigate the influence of pregnancy on prognosis of thyroid cancer.
A total of 72 patients aged between 15-45 years who underwent total or subtotal thyroidectomy and subsequently radioablation were followed up under suppression. Individuals who had term pregnancies after diagnosis of cancer (group 1, n: 36) and who were non-pregnant (group 2, n:36) were included in the study. Both groups were compared in terms of scintigraphic relapse and metastasis, ultrasonographic relapse, stage change of lympadenopathy at the beginning and at the end of the study.
Relapse was detected in 4 out of 36 pregnant patients (11.1%) and in 5 out of 36 non-pregnant patients (13.9%) with no significant difference between groups (p=1.00). Pathologic lymphadenopathy was detected in 2 out of 36 pregnant patients (5.6%) and in 2 out of 36 non-pregnant patients (5.6%) (p=1.00), and metastasis in 3 (8.3%) and in 1 (2.8%), respectively (p=0.61). While stage change was detected in only one pregnant patient (2.8%), and none of the non-pregnant again there was no significant difference (p=1.00).
We conclude that pregnancy does not have an influence on prognosis of thyroid cancer.
本研究旨在探讨妊娠对甲状腺癌预后的影响。
对72例年龄在15 - 45岁之间、接受了甲状腺全切或次全切手术并随后进行放射性消融的患者进行抑制状态下的随访。纳入了癌症诊断后足月妊娠的个体(第1组,n = 36)和未妊娠的个体(第2组,n = 36)。比较两组在闪烁扫描复发和转移、超声复发、研究开始和结束时淋巴结病分期变化方面的情况。
36例妊娠患者中有4例(11.1%)检测到复发,36例未妊娠患者中有5例(13.9%)检测到复发,两组之间无显著差异(p = 1.00)。36例妊娠患者中有2例(5.6%)检测到病理性淋巴结病,36例未妊娠患者中有2例(5.6%)(p = 1.00),分别有3例(8.3%)和1例(2.8%)发生转移(p = 0.61)。仅1例妊娠患者(2.8%)检测到分期变化,未妊娠患者均未出现分期变化,两者无显著差异(p = 1.00)。
我们得出结论,妊娠对甲状腺癌的预后没有影响。