[新疆维吾尔族、汉族和哈萨克族糖尿病前期人群血清尿酸水平及代谢综合征分布的横断面研究]

[A cross-sectional study on serum uric acid level and the distribution of metabolic syndrome among Uigur, Han and Kazak prediabetic groups in Xinjiang].

作者信息

Zhang Hong-wu, Jiang Sheng, Xu Yan-cheng

机构信息

Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuchang 430071, China; Department of Endocrinology, People's Hospital of Xinjiang Uygur Autonomous Region.

Department of Endocrinology, First Affiliate Hospital of Xinjiang Medical University.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2013 Oct;34(10):958-60.

PMID:24377985

Abstract

OBJECTIVE

To explore the levels of uric acid, blood pressure, serum lipid metabolic disorders and the distribution of obesity and metabolic syndrome (MS) among Uygur, Han and Kazak pre-diabetic groups in Xinjiang.

METHODS

A cross-sectional study was conducted on 2053 Uygur residents, 2219 Kazak residents and 2656 Han residents aged 30-80, all with prediabetic syndromes. The pre-dialectic patients were divided into three groups for analysis on metabolic features and inter-group comparisons.

RESULTS

(1)In total, 1934 pre-diabetic cases (28.3%)were diagnosed, with the highest prevalence (31.6%) seen in Uygurs and the lowest (25.5%) in Kazaks and medium (27.0%) in Hans. Data from the inter-group comparison showed statistically significant differences (P = 0.00). (2)Prevalence of high LDL-C was 80.5% , with hyperuricemia as 30.3% and MS as 58.3% , while the inter-group comparison did not show any statistically significant differences (P > 0.05). (3) Prevalence of pre-diabetic when combined with hypertension or earlier-stage hypertension, reached 88.0%, with the highest (96.8%) among Kazak group, 85.1% in Uygurs and 83.7% in Han population. Data from the inter-group comparison showed statistically significant difference(χ(2) = 59.959, P = 0.00). (4)The overall prevalence of prediabetic, when combined with obesity was 35.4%, with 29.6% in Han, 36.8% in Uygur and 41.0% in Kazak groups. Data from the inter-group comparison showed statistically significant difference(χ(2) = 19.097, P = 0.00).

CONCLUSION

According to results from this cross-sectional study regarding the metabolic features of Uygur, Kazak and Han prediabetic groups, differences were seen in the prevalence rates of pre-diabetic among Uygur, Kazak and Han ethnic groups, with the highest seen in Uygurs and the lowest in Kazaks. Hyperlipidemia, hypertension, hyperuricemia,MS and obesity were commonly seen in all the prediabetic groups, with the highest prevalence of hypertension seen in the Kazak group and the highest rate of obesity in Uygur group.

摘要

目的

探讨新疆维吾尔族、汉族和哈萨克族糖尿病前期人群的尿酸、血压、血脂代谢紊乱水平以及肥胖和代谢综合征（MS）的分布情况。

方法

对2053名30 - 80岁的维吾尔族居民、2219名哈萨克族居民和2656名汉族居民进行横断面研究，这些居民均患有糖尿病前期综合征。将糖尿病前期患者分为三组进行代谢特征分析和组间比较。

结果

（1）共诊断出1934例糖尿病前期病例（28.3%），其中维吾尔族患病率最高（31.6%），哈萨克族最低（25.5%），汉族居中（27.0%）。组间比较数据显示差异有统计学意义（P = 0.00）。（2）高LDL - C患病率为80.5%，高尿酸血症为30.3%，MS为58.3%，组间比较差异无统计学意义（P > 0.05）。（3）糖尿病前期合并高血压或早期高血压的患病率达88.0%，其中哈萨克族组最高（96.8%），维吾尔族为85.1%，汉族为83.7%。组间比较数据显示差异有统计学意义（χ(2)=59.959，P = 0.00）。（4）糖尿病前期合并肥胖的总体患病率为35.4%，汉族为29.6%，维吾尔族为36.8%，哈萨克族为41.0%。组间比较数据显示差异有统计学意义（χ(2)=19.097，P = 0.00）。