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[65岁以上使用多种药物治疗患者按活性成分统计的治疗依从性]

[Adherence to treatment, by active ingredient, in patients over 65 years on multiple medication].

作者信息

Núñez Montenegro Antonio J, Montiel Luque Alonso, Martín Aurioles Esther, Torres Verdú Barbara, Lara Moreno Celinda, González Correa José Antonio

机构信息

Área Sanitaria Norte de Málaga, Málaga, España.

San Miguel, Distrito Sanitario Costa del Sol, Torremolinos, Málaga, España.

出版信息

Aten Primaria. 2014 May;46(5):238-45. doi: 10.1016/j.aprim.2013.10.003. Epub 2013 Dec 27.

Abstract

AIM

To assess the level of adherence, by active ingredient, to treatment and associated factors in polymedicated patients over 65 years-old.

DESIGN

Observational, descriptive and cross-sectional study over polymedicated patients over 65 years of the Costa del Sol Health District and the North Malaga Health Area. The study was performed between January 2011 and September 2012 on 375 subjects obtained by simple random sampling from lists provided by each health centre. Data was collected by means of an interview with structured questions. Informed consent was given and signed by all patients before interview.

STUDY VARIABLES

Main results variable adherence to treatment (Morisky-Green's test).

PREDICTABLE VARIABLES

Prescription by active ingredient, socio-demographic variables, health care centre variables, and treatment associated variables. A descriptive analysis of variables was performed. Statistical inference was determined using univariate analysis (t test of Student or Mann-Whitney U, and Chi-squared), and controlling for confounding factors by multivariate analysis (linear and logistic regression).

RESULTS

The result for therapeutic compliance was 51.7%. No statistically significant differences were observed as regards sex and age. A relationship was found in those who resided in rural areas (P=.001), lived with family (P<.05), and were not at risk of suffering from anxiety (P=.046).

CONCLUSIONS

We found similar patient adherence to treatment despite the prescribing generic drugs. Failure to therapeutic compliance was greater in those patients who lived by themselves, in a city close to the coast, or in those patients who were at risk of suffering from anxiety.

摘要

目的

评估65岁以上使用多种药物治疗的患者按有效成分计算的治疗依从性水平及相关因素。

设计

对太阳海岸健康区和马拉加北部健康区65岁以上使用多种药物治疗的患者进行观察性、描述性横断面研究。该研究于2011年1月至2012年9月进行,从每个健康中心提供的名单中通过简单随机抽样选取375名受试者。通过结构化问题访谈收集数据。在访谈前,所有患者均签署了知情同意书。

研究变量

主要结果变量为治疗依从性(Morisky-Green测试)。

可预测变量

按有效成分的处方、社会人口统计学变量、医疗保健中心变量以及与治疗相关的变量。对变量进行了描述性分析。使用单变量分析(Student t检验或Mann-Whitney U检验以及卡方检验)确定统计推断,并通过多变量分析(线性和逻辑回归)控制混杂因素。

结果

治疗依从性结果为51.7%。在性别和年龄方面未观察到统计学上的显著差异。发现居住在农村地区的患者(P = .001)、与家人同住的患者(P < .05)以及没有焦虑风险的患者(P = .046)存在相关性。

结论

尽管开了通用药物,我们发现患者的治疗依从性相似。独居、居住在靠近海岸的城市或有焦虑风险的患者治疗依从性较差。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6778/6983607/a3ad1b3cae77/fx1.jpg

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