Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ziemssenstraße 1, 80336 München, Germany.
Mediators Inflamm. 2013;2013:731023. doi: 10.1155/2013/731023. Epub 2013 Nov 28.
The mononuclear phagocyte system regulates tissue homeostasis as well as all phases of tissue injury and repair. To do so changing tissue environments alter the phenotype of tissue macrophages to assure their support for sustaining and amplifying their respective surrounding environment. Interferon-regulatory factors are intracellular signaling elements that determine the maturation and gene transcription of leukocytes. Here we discuss how several among the 9 interferon-regulatory factors contribute to macrophage polarization.
单核吞噬细胞系统调节组织内稳态以及组织损伤和修复的所有阶段。为此，改变组织环境会改变组织巨噬细胞的表型，以确保它们支持并放大各自的周围环境。干扰素调节因子是决定白细胞成熟和基因转录的细胞内信号转导元件。在这里，我们讨论了 9 种干扰素调节因子中的几种如何促进巨噬细胞极化。
