Mokhtari Mojgan, Taghizadeh Faegheh, Hani Mohsen
Department of Pathology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2013 Aug;18(8):707-10.
Prostatic adenocarcinoma is the most prevalent cancer and the second cause of cancer-related death among men. Human Papilloma Virus (HPV) considered as a preventable risk factor for prostatic adenocarcinoma. In this study, we detected the frequency of HPV infection in prostatic adenocarcinoma and benign prostatic hyperplasia (BPH) in Isfahan.
In this study, 120 paraffin-embedded blocks (90 and 30 cases with definite diagnosis of BPH and adenocarcinoma, respectively) were selected. Immunohistochemical (IHC) staining was performed for all selected blocks to detect HPV infection. The rate of infection was compared in the two studied groups.
Totally, HPV was detected in four blocks. HPV infection was positive in 10% (3/30) of cases with adenocarcinoma and 1.1% (1/90) of cases with BPH (P = 0.04, OR = 9.88, CI 95%). Mean age of patients with positive and negative HPV infection was 61.75 ± 8.3 and 68.51 ± 11.7 years, respectively.
Considering the higher prevalence of HPV infection in prostatic adenocarcinoma, it is suggested that HPV could be probable risk factor for prostatic adenocarcinoma. It is recommended to investigate the prevalence of HPV infection in Iranian men and the outcome of prevention and treatment of HPV infection on prostatic adenocarcinoma.
前列腺腺癌是男性中最常见的癌症，也是癌症相关死亡的第二大原因。人乳头瘤病毒（HPV）被认为是前列腺腺癌的一个可预防风险因素。在本研究中，我们检测了伊斯法罕前列腺腺癌和良性前列腺增生（BPH）中HPV感染的频率。
在本研究中，选取了120个石蜡包埋块（分别为90例和30例确诊为BPH和腺癌的病例）。对所有选取的块进行免疫组织化学（IHC）染色以检测HPV感染。比较两个研究组的感染率。
总共在4个块中检测到HPV。腺癌病例中10%（3/30）HPV感染呈阳性，BPH病例中1.1%（1/90）HPV感染呈阳性（P = 0.04，OR = 9.88，95%CI）。HPV感染阳性和阴性患者的平均年龄分别为61.75±8.3岁和68.51±11.7岁。
鉴于前列腺腺癌中HPV感染的患病率较高，提示HPV可能是前列腺腺癌的风险因素。建议调查伊朗男性中HPV感染的患病率以及HPV感染的预防和治疗对前列腺腺癌的影响。
