Atashafrooz Fatemeh, Rokhbakhsh-Zamin Farokh
Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran E-mail :
Asian Pac J Cancer Prev. 2016;17(8):3953-8.
Prostatic cancer is the second cause of cancer-related death among men worldwide. The human papilloma viruses (HPVs) are a family of sexually transmitted viruses which have may have roles in the etiology of inflammation in the prostate leading to benign prostatic hyperplasia (BPH) and prostate cancer (PCa). In this study, we evaluated the frequency of different HPV types in prostatic cancer and benign prostatic hyperplasia (BPH) in Kerman province, southeast of Iran, using real-time PCR techniques. The aim of the present research was to clarify any association with prostatic carcinogenesis. Real Time PCR showed that HPV DNA was found in 20% of 200 PCa samples, 80 percent of these with high-risk HPV types, 40% with type-16,18, 30 % type-31,33 and 10% type 54. High risk HPV DNA was detected in only 2% of BPH samples. Values for low risk types were much higher. Our study provided support for a role of high risk HPV infection in prostatic disease in Iranian patients, and association between presence of HPV DNA and prostate carcinoma. In particular, HPV 16 and18 might have an important role in prostate cancer.
前列腺癌是全球男性癌症相关死亡的第二大原因。人乳头瘤病毒（HPV）是一类性传播病毒，可能在导致良性前列腺增生（BPH）和前列腺癌（PCa）的前列腺炎症病因中起作用。在本研究中，我们使用实时PCR技术评估了伊朗东南部克尔曼省前列腺癌和良性前列腺增生（BPH）中不同HPV类型的频率。本研究的目的是阐明与前列腺癌发生的任何关联。实时PCR显示，在200份PCa样本中有20%检测到HPV DNA，其中80%为高危HPV类型，40%为16、18型，30%为31、33型，10%为54型。在BPH样本中仅2%检测到高危HPV DNA。低危类型的值要高得多。我们的研究支持高危HPV感染在伊朗患者前列腺疾病中的作用，以及HPV DNA的存在与前列腺癌之间的关联。特别是，HPV 16和18可能在前列腺癌中起重要作用。
