Pendyala Gowri, Joshi Saurabh, Chaudhari Shantanu, Gandhage Dhananjay
Department of Periodontics, Rural Dental College, Loni, Maharashtra, India.
Department of Pedodontics, Rural Dental College, Loni, Maharashtra, India.
Dent Res J (Isfahan). 2013 Nov;10(6):704-12.
Cancer is marked by the uncontrolled growth of cells, tissue invasion and metastasis to various organs via the circulatory and lymphatic systems. Recent data have expanded the concept that inflammation is a critical component of tumor progression. Many cancers arise from sites of infection, chronic irritation, and inflammation. The tumor microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival, and migration. Periodontal disease, a chronic inflammatory condition is characterized by an oral bacterial infection leading to inflammation within the supporting tissues of the teeth, which often leads to the destruction of the periodontal tissues and alveolar bone that support the teeth. This oral inflammation often has systemic effects leading to an increased concentration of circulating inflammatory markers with the severity of disease being correlated directly with levels of serum inflammatory markers. Periodontal infection has been linked to organ and systemic diseases. There is documented evidence of significant associations between cancer of the lung, kidney, pancreas, hematological and oral cancers, and periodontal disease. This articles reviews and summarizes the possible biological mechanisms involved between periodontal infection and cancer.
癌症的特征是细胞不受控制地生长、组织侵袭以及通过循环系统和淋巴系统转移至各个器官。最近的数据扩展了炎症是肿瘤进展关键组成部分这一概念。许多癌症起源于感染、慢性刺激和炎症部位。肿瘤微环境在很大程度上由炎症细胞调控，是肿瘤形成过程中不可或缺的参与者，促进肿瘤细胞的增殖、存活和迁移。牙周病是一种慢性炎症性疾病，其特征是口腔细菌感染导致牙齿支持组织内的炎症，这通常会导致支持牙齿的牙周组织和牙槽骨遭到破坏。这种口腔炎症通常具有全身影响，导致循环炎症标志物浓度升高，疾病严重程度与血清炎症标志物水平直接相关。牙周感染与器官和全身性疾病有关。有文献记载，肺癌、肾癌、胰腺癌、血液系统癌症和口腔癌与牙周病之间存在显著关联。本文综述并总结了牙周感染与癌症之间可能涉及的生物学机制。
