Yao Qi-Wei, Zhou Dong-Sheng, Peng Hong-Juan, Ji Ping, Liu De-Sheng
School of Stomatology, Shandong University, Jinan, 250012, People's Republic of China.
Tumour Biol. 2014 Jul;35(7):7073-7. doi: 10.1007/s13277-014-1951-8. Epub 2014 Apr 23.
The objective is to evaluate the association of periodontal disease with the risk of oral cancer. Literature retrieval, selection and assessment, data extraction, and meta-analyses were performed according to the RevMan 5.0 guidelines. In the meta-analysis, we utilized random-effect model to pool the odds ratio (OR) according to the test of heterogeneity. A total of five eligible studies included 1,191 oral cancer patients and 1,992 healthy control subjects were analyzed. By meta-analysis, we found a significant association of periodontal disease with oral cancer [OR = 3.53, 95 % CI (1.52-8.23); P = 0.003]. Patients with periodontal disease have increased susceptibility to oral cancer.
目的是评估牙周疾病与口腔癌风险之间的关联。根据RevMan 5.0指南进行文献检索、筛选与评估、数据提取及荟萃分析。在荟萃分析中，我们根据异质性检验采用随机效应模型合并比值比（OR）。总共五项符合条件的研究纳入了1191例口腔癌患者和1992例健康对照受试者并进行分析。通过荟萃分析，我们发现牙周疾病与口腔癌之间存在显著关联[OR = 3.53，95%置信区间（1.52 - 8.23）；P = 0.003]。患有牙周疾病的患者患口腔癌的易感性增加。
