Juarez Dt, Goo R, Tokumaru S, Sentell T, Davis Jw, Mau Mm
College of Pharmacy, University of Hawai'i at Hilo.
Department of Public Health Sciences, John A. Burns School of Medicine, Honolulu, Hawai'i.
Am J Pharm Benefits. 2013;5(2):59-64.
To examine the relationship between sustained glycemic control and health care costs among patients with diabetes with an initial hemoglobin A1c≥9%.
STUDY DESIGN/METHODS: We conducted a retrospective analysis of administrative data from patients with diabetes and initial poor HbA1c control enrolled in a large health plan in Hawai'i (n=1304). We used propensity scores to identify a comparable cohort based on age, gender, type of coverage, diabetes duration, number of medications, location of residence, comorbidity conditions, and morbidity level. We examined the relationship between reduced A1c values and costs in the same year as well as the impact of achieving sustained A1c control (at < 7%)for three years on changes in health care costs using generalized linear models.
In cross-sectional comparisons, the average annual direct medical costs for patients withHbA1c less than 7% was $14,821 compared to $12,108 for the matched sample of patients with A1c greater than or equal to 7%, for a difference of $2,713 95%CI[$285, $5,140]. In contrast, when we examined the change in cost from 2006 to 2009 for patients who had sustained levels of A1c at <7% for all three years, we found that total cost care for patients with sustained control decreased by $2,207 compared to a $3,006 increase for patients without sustained control, for a difference of -$5,214, 95%CI[-$10,163, -$264].
Our study suggests that while reducing hemoglobin A1c levels to target goals may not immediately result in cost reductions, sustained A1c control were associated with lower costs in a three-year time frame.
研究初始糖化血红蛋白A1c≥9%的糖尿病患者持续血糖控制与医疗费用之间的关系。
研究设计/方法:我们对夏威夷一个大型健康计划中初始糖化血红蛋白A1c控制不佳的糖尿病患者的管理数据进行了回顾性分析(n = 1304)。我们使用倾向得分,根据年龄、性别、保险类型、糖尿病病程、用药数量、居住地点、合并症情况和发病程度来确定一个可比队列。我们使用广义线性模型研究了同年糖化血红蛋白A1c值降低与费用之间的关系,以及三年实现持续糖化血红蛋白A1c控制(<7%)对医疗费用变化的影响。
在横断面比较中,糖化血红蛋白A1c低于7%的患者平均每年直接医疗费用为14,821美元,而糖化血红蛋白A1c大于或等于7%的匹配样本患者为12,108美元,相差2,713美元[95%置信区间(CI):285美元,5,140美元]。相比之下,当我们研究2006年至2009年期间三年糖化血红蛋白A1c持续维持在<7%的患者的费用变化时,我们发现持续控制的患者总医疗费用减少了2,207美元,而未持续控制的患者增加了3,006美元,相差 -5,214美元[95%CI:-10,163美元,-264美元]。
我们的研究表明,虽然将糖化血红蛋白A1c水平降至目标值可能不会立即降低成本,但在三年时间范围内,持续的糖化血红蛋白A1c控制与较低的成本相关。