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1 型糖尿病护理:糖尿病康复诊所标准化的改进。观察报告。

Type 1 diabetes care: Improvement by standardization in a diabetes rehabilitation clinic. An observational report.

机构信息

Department of Laboratory Medicine, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria.

Rehabilitation Clinic for Diabetes and Metabolic Diseases, Moorbad Neydharting, Neydharting 4, Bad Wimsbach-Neydharting, Austria.

出版信息

PLoS One. 2018 Mar 12;13(3):e0194135. doi: 10.1371/journal.pone.0194135. eCollection 2018.

Abstract

BACKGROUND

T1D treatment requires informed self-responsible patients, who, however, frequently miss their therapeutic goals, providing considerable potential for improvement.

METHODS

This observational report evaluates T1D patients [N = 109], aged ≥18 years (range 22-82), poorly controlled at home, at and 3 weeks after their admission to our diabetes rehabilitation clinic [DRC], where they were offered standardized, but unmonitored life-style modification.

RESULTS

At admission, patients displayed elevated HbA1c values (66 mmol/mol [57; 81]), a high prevalence of co-morbidities (88%), lipodystrophies due to monolocal insulin injections (42%), a low rate of influenza (16%) and pneumococcal (7%) immunization, and underuse of lipid-lowering drugs (-38%). Standardization of life-style improved glucose (p<0.0001) and lipid metabolism (LDL/HDL ratio p<0.01) permitting reduction of insulin dose and reduction of add-on glucose-lowering drugs (GLDs) other than metformin. Outcome was independent of the mode of insulin treatment strategy and more marked at initially high HbA1c, with DRC-costs/d less than 25% of those encountered at standard hospitals.

CONCLUSION

Type 1 diabetes care requires i) insulin treatment, food intake and life style to be handled in concert, ii) this need cannot be replaced by arbitrary addition of add-on GLDs, and iii) training to this end is 75% cheaper at a DRC than in standard hospitals.

摘要

背景

T1D 治疗需要有知情的、有自我责任感的患者,但患者经常未能达到治疗目标,这为提高治疗效果提供了很大的潜力。

方法

本观察报告评估了 109 名年龄≥18 岁(范围 22-82 岁)的 T1D 患者,这些患者在家中血糖控制不佳,在入住我们的糖尿病康复诊所(DRC)时和入住后 3 周进行评估,他们在 DRC 接受了标准化但未监测的生活方式改变。

结果

在入院时,患者的 HbA1c 值升高(66mmol/mol[57;81]),合并症患病率高(88%),由于单部位胰岛素注射导致脂肪营养不良(42%),流感(16%)和肺炎球菌(7%)疫苗接种率低,以及降脂药物使用率低(-38%)。生活方式的标准化改善了血糖(p<0.0001)和血脂代谢(LDL/HDL 比值 p<0.01),允许减少胰岛素剂量和减少除二甲双胍以外的其他降糖药物(GLD)的添加。结果独立于胰岛素治疗策略的模式,并且在初始 HbA1c 较高时更为显著,DRC 成本/天不到标准医院的 25%。

结论

1 型糖尿病的治疗需要 i)胰岛素治疗、饮食摄入和生活方式的协调处理,ii)这种需求不能通过任意添加 GLD 来替代,iii)这种培训在 DRC 比在标准医院便宜 75%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e7/5847233/a6f2b20ac773/pone.0194135.g001.jpg

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