Ishiguro S, Nishio A, Miyao N, Morikawa Y, Takeno K, Yanagiya I
Nihon Yakurigaku Zasshi. 1987 Mar;89(3):121-7. doi: 10.1254/fpj.89.121.
The effects of dietary magnesium (Mg) deficiency on dermal mast cells were studied in young Wistar rats weighing about 50 g. The rats fed with a Mg-deficient diet (0.001% Mg) showed hyperemia on the 3rd or the 4th day after they were fed the diet. The dermal mast cells of the control rats were filled with granules, while the cells of rats fed the Mg-deficient diet for 4 days contained less granules than the controls, but contained extensively dilated rough surfaced endoplasmic reticulum, well-developed Golgi complexes, many mitochondria and ribosomes. These data suggest that hypomagnesemia could induce a release of histamine from dermal mast cells. So, the effect of a low Mg medium on the release of histamine was studied using peritoneal mast cells in vitro. A low Mg medium (0.2 mM Mg) induced much more histamine release than control medium (1 mM Mg) from the peritoneal mast cells obtained from both control and Mg-deficient rats fed with the Mg-deficient diet for 2 days. The peritoneal mast cells obtained on the 8th day of Mg-deficiency released much more histamine than controls in 1 mM Mg medium. These results suggest that hyperemia observed in Mg-deficient rats depends partly on histamine released from dermal mast cells.
在体重约50克的幼年Wistar大鼠中研究了饮食中镁（Mg）缺乏对皮肤肥大细胞的影响。喂食缺镁饮食（0.001%镁）的大鼠在喂食该饮食后的第3天或第4天出现充血。对照大鼠的皮肤肥大细胞充满颗粒，而喂食缺镁饮食4天的大鼠的细胞所含颗粒比对照少，但含有广泛扩张的糙面内质网、发达的高尔基体、许多线粒体和核糖体。这些数据表明低镁血症可诱导皮肤肥大细胞释放组胺。因此，使用腹膜肥大细胞在体外研究了低镁培养基对组胺释放的影响。低镁培养基（0.2 mM镁）比对照培养基（1 mM镁）诱导来自对照和喂食缺镁饮食2天的缺镁大鼠的腹膜肥大细胞释放更多的组胺。在缺镁第8天获得的腹膜肥大细胞在1 mM镁培养基中释放的组胺比对照多得多。这些结果表明，在缺镁大鼠中观察到的充血部分取决于皮肤肥大细胞释放的组胺。
