O'Brien Caitlin E, Wyss-Coray Tony
Cell and Molecular Biology Program, Stanford University, Stanford, CA, 94305, USA.
J Neuroimmune Pharmacol. 2014 Jun;9(3):285-92. doi: 10.1007/s11481-013-9519-8. Epub 2014 Jan 3.
Beclin 1 has a well-established role in regulating autophagy, a cellular degradation pathway. Although the yeast ortholog of beclin 1 (Atg6/Vps30) was discovered to also regulate vacuolar protein sorting nearly 30 years ago, the varied functions of beclin 1 in mammalian cells are only beginning to be sorted out. We recently described a role for beclin 1 in regulating recycling of phagocytic receptors in microglia, a function analogous to that of its yeast ortholog. Microglia lacking beclin 1 have a reduced phagocytic capacity, which impairs clearance of amyloid β (Aβ) in a mouse model of Alzheimer's Disease (AD). Here we summarize these findings and discuss the implications for beclin 1-regulated receptor recycling in neurodegenerative disease.
Beclin 1在调节自噬（一种细胞降解途径）方面具有已被充分证实的作用。尽管近30年前就发现Beclin 1的酵母同源物（Atg6/Vps30）也调节液泡蛋白分选，但Beclin 1在哺乳动物细胞中的多种功能才刚刚开始被梳理清楚。我们最近描述了Beclin 1在调节小胶质细胞中吞噬受体再循环方面的作用，这一功能与其酵母同源物类似。缺乏Beclin 1的小胶质细胞吞噬能力降低，这损害了阿尔茨海默病（AD）小鼠模型中β淀粉样蛋白（Aβ）的清除。在这里，我们总结这些发现，并讨论Beclin 1调节的受体再循环在神经退行性疾病中的意义。
