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促进干细胞介导骨生成的仿生聚合物支架

Biomimetic polymer scaffolds to promote stem cell-mediated osteogenesis.

作者信息

Ko Eunkyung, Cho Seung-Woo

机构信息

Department of Biotechnology, Yonsei University, Seoul, Korea.

出版信息

Int J Stem Cells. 2013 Nov;6(2):87-91. doi: 10.15283/ijsc.2013.6.2.87.

DOI:10.15283/ijsc.2013.6.2.87
PMID:24386552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3878208/
Abstract

Bone tissue engineering using stem cells with osteogenic potential is a promising avenue of research for bone defect reconstruction. Organic, inorganic, and composite scaffolds have all been engineered to provide biomimetic microenvironments for stem cells. These scaffolds are designed to promote stem cell osteogenesis. Here, we review current technologies for developing biomimetic, osteoinductive scaffolds for stem cell applications. We summarize the reported in vitro and in vivo osteogenic effects of these scaffolds on stem cells.

摘要

利用具有成骨潜能的干细胞进行骨组织工程是骨缺损修复研究中一条很有前景的途径。有机、无机和复合支架都已被设计用于为干细胞提供仿生微环境。这些支架旨在促进干细胞成骨。在此，我们综述了当前用于开发用于干细胞应用的仿生、骨诱导支架的技术。我们总结了这些支架对干细胞的体外和体内成骨作用的报道。