Department of Orthopedic Surgery, School of Medicine, Nagasaki University , 1-7-1 Sakamoto, Nagasaki 852-8501 , Japan.
Mod Rheumatol. 2003 Dec;13(4):371-3. doi: 10.3109/s10165-003-0240-y.
Abstract Pachydermoperiostosis (PDP) is characterized by clubbing fingers, furrowing of the facial skin, and perio-steal hypertrophy. We report a case of a patient with PDP associated with severe arthritis of the knee and ankle joints. His serum C-reactive protein (CRP) levels were increased, and an analysis of serum and synovial fluid showed high levels of interleukin-6. These findings mean that there is some difficulty in distinguishing the disease from rheumatoid arthritis. While treatments such as nonsteroidal anti-inflammatory drugs, steroids, and colchicine were not particularly effective, the severe arthralgia was gradually relieved over a few years.
摘要 厚皮性骨膜病（PDP）的特征为杵状指、面部皮肤皱纹和骨膜增生。我们报告一例 PDP 患者，其伴发严重的膝关节和踝关节关节炎。他的血清 C 反应蛋白（CRP）水平升高，血清和滑液分析显示白细胞介素-6 水平升高。这些发现意味着该疾病与类风湿关节炎的鉴别有些困难。非甾体抗炎药、类固醇和秋水仙碱等治疗效果并不特别显著，但是几年后严重的关节痛逐渐缓解。
