Tabatabaei Seyed Ali, Masoomi Ahmad, Soleimani Mohammad, Rafizadeh Seyed Mohsen, Salabati Mirataollah, Ahmadraji Aliasghar, Bohrani Bahram, Ghahvechian Hossein, Nozarian Zohreh
Ocular Trauma and Emergency Department, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Pathology Department, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
J Curr Ophthalmol. 2019 Mar 29;31(4):450-453. doi: 10.1016/j.joco.2019.03.001. eCollection 2019 Dec.
To report a case of pachydermoperiostosis (PDP) and a review of the literature.
A 32-year-old man was referred to our clinic with bilateral eyelid swelling and blepharoptosis. On examination, marked blepharoptosis was noted, and his eyelids were found to be floppy. Systemic examination was significant for clubbing of digits, coarse acromegalic facial features, and furrowing and oiliness of the skin of scalp and forehead.
The patient was diagnosed as a case of PDP. On the brain MRI, the pituitary gland was enlarged, and the border of clivus was irregular. Pituitary and thyroid hormone levels were normal. He underwent bilateral lateral tarsal strip (LTS) procedure to address the eyelid laxity. Histopathologic examination revealed marked sebaceous gland hyperplasia with mucin deposition in the dermis.
Floppy eyelid syndrome, clubbing, and acromegaloid face are main features that could lead to the diagnosis of PDP.
报告一例厚皮性骨膜病（PDP）病例并对文献进行综述。
一名32岁男性因双侧眼睑肿胀及上睑下垂转诊至我院门诊。检查发现明显的上睑下垂，且眼睑松弛。全身检查显示手指杵状指、肢端肥大症面容粗糙以及头皮和前额皮肤有皱纹且油腻。
该患者被诊断为PDP病例。脑部磁共振成像（MRI）显示垂体增大，斜坡边界不规则。垂体和甲状腺激素水平正常。他接受了双侧外侧睑板条（LTS）手术以解决眼睑松弛问题。组织病理学检查显示皮脂腺明显增生，真皮内有粘蛋白沉积。
眼睑松弛综合征、杵状指和肢端肥大症面容是有助于诊断PDP的主要特征。
