Mustakallio K K, Brandt H
Acta Derm Venereol. 1984;64(1):63-6.
Dithranol, 10-propionyl dithranol and 10-butyryl dithranol were compared as regards their antipsoriatic, staining and irritative properties. They were applied under 12-mm Finnchambers on the lesional skin of 17 psoriasis patients every second day for 20 days. In 9 patients their concentration was equimolar (2 mmol/kg of white petrolatum) corresponding to 0.05% dithranol, and in 8 patients the concentrations were 2, 4, and 8 mmol for dithranol, 10-propionyl dithranol and 10-butyryl dithranol, respectively. Without regard to the concentration, they all produced under occlusion almost equal thinning of the lesions, but when a 2 mmol concentration was used, 10-butyryl dithranol (butantrone) showed least staining and irritation on the treated sites.
对蒽林、10-丙酰基蒽林和10-丁酰基蒽林的抗银屑病、染色和刺激性进行了比较。每隔一天将它们涂于17例银屑病患者皮损处的12毫米Finnchambers下，持续20天。9例患者使用等摩尔浓度（2毫摩尔/千克白凡士林），相当于0.05%蒽林，8例患者中，蒽林、10-丙酰基蒽林和10-丁酰基蒽林的浓度分别为2、4和8毫摩尔。无论浓度如何，在封包情况下它们都能使皮损几乎同等程度变薄，但当使用2毫摩尔浓度时，10-丁酰基蒽林（丁酮）在治疗部位的染色和刺激最小。
