Shiraishi Rikiya, Nishimura Masaaki, Nakashima Ryuji, Enta Chiho, Hirayama Norio
Research Institute for Animal Science in Biochemistry & Toxicology, 3-7-11 Hashimotodai, Midori-ku, Sagamihara, Kanagawa 252-0132, Japan.
J Vet Med Sci. 2014 Apr;76(4):605-9. doi: 10.1292/jvms.13-0335. Epub 2013 Dec 31.
In Japan, the import quarantine regulation against rabies has required from 2005 that dogs and cats should be inoculated with the rabies vaccine and that the neutralizing antibody titer should be confirmed to be at least 0.5 international units (IU)/ml. The fluorescent antibody virus neutralization (FAVN) test is used as an international standard method for serological testing for rabies. To achieve proper immunization of dogs and cats at the time of import and export, changes in the neutralizing antibody titer after inoculation of the rabies vaccine should be understood in detail. However, few reports have provided this information. In this study, we aimed to determine evaluated, such changes by using sera from experimental dogs and cats inoculated with the rabies vaccine, and we tested samples using the routine FAVN test. In both dogs and cats, proper, regular vaccination enabled the necessary titer of neutralizing antibodies to be maintained in the long term. However, inappropriate timing of blood sampling after vaccination could result in insufficient detected levels of neutralizing antibodies.
在日本，自2005年起，针对狂犬病的进口检疫规定要求犬猫接种狂犬病疫苗，并确认中和抗体效价至少为0.5国际单位（IU）/毫升。荧光抗体病毒中和（FAVN）试验被用作狂犬病血清学检测的国际标准方法。为了在进出口时实现犬猫的适当免疫，应详细了解接种狂犬病疫苗后中和抗体效价的变化。然而，很少有报告提供这方面的信息。在本研究中，我们旨在通过使用接种狂犬病疫苗的实验犬猫的血清来确定、评估此类变化，并使用常规FAVN试验对样本进行检测。在犬和猫中，适当、定期的疫苗接种能够长期维持必要的中和抗体效价。然而，接种疫苗后采血时间不当可能导致检测到的中和抗体水平不足。
