Department of Reproductive Medicine, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310021, China.
J Zhejiang Univ Sci B. 2014 Jan;15(1):51-7. doi: 10.1631/jzus.B1300229.
To explore whether there exist differences in cognitive development between singletons and twins born after in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).
A total of 566 children were recruited for the study, including 388 children (singletons, n=175; twins, n=213) born after IVF and 178 children (singletons, n=87; twins, n=91) born after ICSI. The cognitive development was assessed using the Chinese-Wechsler Intelligence Scale for Children (C-WISC).
For all pre-term offspring, all the intelligence quotient (IQ) items between singletons and twins showed no significant differences no matter if they were born after IVF or ICSI. There was a significant difference in the cognitive development of IVF-conceived full-term singletons and twins. The twins born after IVF obtained significantly lower scores than the singletons in verbal IQ (containing information, picture & vocabulary, arithmetic, picture completion, comprehension, and language), performance IQ (containing maze, visual analysis, object assembly, and performance), and full scale IQ (P<0.05). The cognitive development of full-term singletons and twins born after ICSI did not show any significant differences. There was no significant difference between the parents of the singletons and twins in their characteristics where data were collected, including the age of the mothers, the current employment status, the educational backgrounds, and areas of residence. There were also no consistent differences in the duration of pregnancy, sex composition of the children, age, and height between singletons and twins at the time of our study although there existed significant differences between the two groups in the sex composition of the full-term children born after ICSI (P<0.05).
Compared to the full-term singletons born after IVF, the full-term twins have lower cognitive development. The cognitive development of full-term singletons and twins born after ICSI did not show any significant differences. For all pre-term offspring, singletons and twins born after IVF or ICSI, the results of the cognitive development showed no significant differences.
探讨体外受精（IVF）或卵胞浆内单精子注射（ICSI）后出生的单胎和双胎在认知发育方面是否存在差异。
共纳入 566 名儿童进行研究，包括 388 名儿童（IVF 出生，单胎 175 例，双胎 213 例；ICSI 出生，单胎 87 例，双胎 91 例）。采用中国韦氏儿童智力量表（C-WISC）评估认知发育情况。
对于所有早产儿，IVF 或 ICSI 后出生的单胎和双胎的所有智商（IQ）项目均无显著差异。IVF 足月单胎和双胎的认知发育存在显著差异。IVF 足月双胎的言语智商（包含信息、图片和词汇、算术、图片填空、理解和语言）、操作智商（包含迷宫、视觉分析、物体组装和操作）和全量表智商得分均显著低于单胎（P<0.05）。ICSI 后足月单胎和双胎的认知发育无显著差异。在收集数据的特征方面，单胎和双胎的父母没有明显差异，包括母亲年龄、当前就业状况、教育背景和居住地。虽然 ICSI 后足月出生的儿童在性别构成、妊娠持续时间、儿童性别构成、年龄和身高方面存在显著差异（P<0.05），但单胎和双胎之间这些方面的差异并不一致。
与 IVF 足月单胎相比，IVF 足月双胎的认知发育较低。ICSI 后足月单胎和双胎的认知发育无显著差异。对于所有早产儿，IVF 或 ICSI 后出生的单胎和双胎，认知发育结果无显著差异。
