Vaccinology Theme, Medical Research Council Unit, Fajara, The Gambia.
Statistics and Data Management Department, Medical Research Council Unit, Fajara, The Gambia.
Trop Med Int Health. 2014 Mar;19(3):275-283. doi: 10.1111/tmi.12245. Epub 2014 Jan 7.
To establish haematological and biological reference values for Gambian infants.
Basic haematological and biochemical indices were analysed in blood samples obtained from healthy infants from Sukuta in the Western Division of The Gambia. The 2.5 and the 97.5 centiles for these indices were estimated.
Reference ranges for haematological and biochemical indices were determined. Haemoglobin, total white cell count (WBC) and platelet levels decreased with age (P < 0.001), whereas most of the white cell count subsets except monocytes did not vary with age. Potassium and alkaline phosphatase fell significantly with increasing age (P < 0.001; P < 0.001), whereas urea and creatinine rose with increasing age (P = 0.002; P < 0.001, respectively).
Our set of haematological and biochemical reference values for healthy infants in The Gambia differs from values in other settings, thus underscoring the importance of establishing region-specific paediatric reference ranges to ensure optimal patient management and evaluate the impact of interventions in clinical research.
建立冈比亚婴儿的血液学和生物学参考值。
对来自冈比亚西部苏库塔地区健康婴儿的血液样本进行基本血液学和生化学指标分析。估计这些指标的第 2.5 和第 97.5 百分位数。
确定了血液学和生化学指标的参考范围。血红蛋白、总白细胞计数（WBC）和血小板水平随年龄增长而降低（P<0.001），而除单核细胞外的大多数白细胞计数亚群随年龄变化不大。钾和碱性磷酸酶随年龄增长显著下降（P<0.001；P<0.001），而尿素和肌酐随年龄增长而升高（P=0.002；P<0.001）。
我们为冈比亚健康婴儿制定的血液学和生化学参考值与其他地区的数值不同，因此强调建立特定于区域的儿科参考范围以确保最佳患者管理和评估临床研究中干预措施的影响的重要性。
