Taylor M R, Holland C V, Spencer R, Jackson J F, O'Connor G I, O'Donnell J R
Department of Paediatrics, Trinity College Dublin, Ireland.
Clin Lab Haematol. 1997 Mar;19(1):1-15. doi: 10.1046/j.1365-2257.1997.00204.x.
There are few reports of reference ranges for haematological values in school age children and most studies extend over a small age range or have excluded a considerable proportion of the study population in an effort to omit those with haemoglobinopathies or anaemia. Blood samples from 2135 children aged 4-19 years, from randomly selected schools, were analysed by automated counter. Reference ranges for red cell, white cell and platelet indices are provided from the results. Median haemoglobin and red blood cell count values for girls and boys rose together with increasing age, up to 12 years, but then diverged. Girls had a higher platelet count than boys. Mean platelet volume rose with age and was inversely related to the platelet count. Plateletcrit fell with age but in girls there was a peri-pubertal peak. Total leucocyte count fell with age. The upper limits for total leucocyte count in this study are approximately 2 x 10(9) lower than those quoted in modern haematology textbooks. Lymphocyte, eosinophil and basophil counts fell with age with little difference between the sexes. Neutrophil and monocyte counts were similar for younger girls and boys but diverged in the older children with the older girls having higher values than boys.
关于学龄儿童血液学指标参考范围的报道较少,大多数研究的年龄范围较小,或者为了排除患有血红蛋白病或贫血的儿童而将相当一部分研究人群排除在外。对从随机选择的学校中抽取的2135名4至19岁儿童的血样进行了自动计数分析。根据结果给出了红细胞、白细胞和血小板指标的参考范围。女孩和男孩的血红蛋白中位数和红细胞计数随着年龄增长而上升,直至12岁,但随后出现差异。女孩的血小板计数高于男孩。平均血小板体积随年龄增长而上升,且与血小板计数呈负相关。血小板压积随年龄下降,但女孩在青春期前后有一个峰值。白细胞总数随年龄下降。本研究中白细胞总数的上限比现代血液学教科书中引用的数值低约2×10⁹。淋巴细胞、嗜酸性粒细胞和嗜碱性粒细胞计数随年龄下降,两性之间差异不大。年龄较小的女孩和男孩的中性粒细胞和单核细胞计数相似,但在年龄较大的儿童中出现差异,年龄较大的女孩数值高于男孩。