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西非几内亚比绍4至5.5个月大婴儿血液学参数的季节性和性别特异性变化。

Seasonal and sex-specific variations in haematological parameters in 4 to 5.5-month-old infants in Guinea-Bissau, West Africa.

作者信息

Bæk Ole, Jensen Kristoffer Jarlov, Andersen Andreas, Balé Carlito, Martins Cesario, Biering-Sørensen Sofie, Poulsen Anja, Benn Christine Stabell

机构信息

Bandim Health Project, Indepth Network, codex 1004, Bissau, Guinea-Bissau.

Department of Infectious Diseases, Hvidovre Hospital, DK-2650 Copenhagen, Denmark.

出版信息

Trans R Soc Trop Med Hyg. 2017 Jan 1;111(1):30-37. doi: 10.1093/trstmh/trx014.

DOI:10.1093/trstmh/trx014
PMID:28371872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5914425/
Abstract

OBJECTIVE

This study investigated seasonal and sex-specific variations in the haematological parameters and established reference ranges for these parameters in healthy 4 to 5.5-month-old infants in Guinea-Bissau.

METHODS

Within a randomised trial of early measles vaccination, over a period of 13 months blood samples were collected from infants aged 4 to 5.5 months. Haematological parameters were determined by an automated cell counter and compared in linear regression models providing geometric mean ratios (GMR).

RESULTS

Blood samples from 501 infants (n=248 boys, 49.5%) were obtained, and 285 (56.9%) were collected in the rainy season. Median age was 4.7 months (range 3.7 to 7.2 months). Eosinophil and platelet counts were lower in the dry season (December to May) than in the rainy season (GMR 0.79 [95% CI 0.68-0.92]) and 0.93 [0.87-1.00], respectively). The calculated reference ranges were wider and generally higher than those from a US population of comparable age, but neutrophil levels were notably lower in Guinea-Bissau.

CONCLUSIONS

The study indicated that eosinophil and platelet counts of infants were subject to seasonal variations. The reference ranges for haematological values were comparable to other African populations and corroborated that neutropenia regularly occurs in African infants.

摘要

目的

本研究调查了几内亚比绍4至5.5个月大健康婴儿血液学参数的季节性和性别特异性变化，并确定了这些参数的参考范围。

方法

在一项早期麻疹疫苗接种随机试验中，在13个月的时间里收集了4至5.5个月大婴儿的血样。血液学参数由自动血细胞计数器测定，并在提供几何平均比（GMR）的线性回归模型中进行比较。

结果

获得了501名婴儿（n = 248名男孩，49.5%）的血样，其中285份（56.9%）在雨季采集。中位年龄为4.7个月（范围3.7至7.2个月）。旱季（12月至5月）的嗜酸性粒细胞和血小板计数低于雨季，几何平均比分别为0.79[95%可信区间0.68 - 0.92]和0.93[0.87 - 1.00]。计算出的参考范围比美国同龄人群的参考范围更宽且总体更高，但几内亚比绍的中性粒细胞水平明显较低。

结论

该研究表明婴儿的嗜酸性粒细胞和血小板计数存在季节性变化。血液学值的参考范围与其他非洲人群相当，并证实非洲婴儿经常出现中性粒细胞减少症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82eb/5914425/7d8a6ea342f4/trx014f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82eb/5914425/7d8a6ea342f4/trx014f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82eb/5914425/7d8a6ea342f4/trx014f01.jpg

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