Sponder Michael, Dangl Daniela, Kampf Stephanie, Fritzer-Szekeres Monika, Strametz-Juranek Jeanette
Department of Cardiology, Institute of Internal Medicine II, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria.
Cardiovasc Diabetol. 2014 Jan 6;13:6. doi: 10.1186/1475-2840-13-6.
Type 2 diabetes mellitus (T2DM) is often associated with atherosclerotic changes in coronary vessels, most notably plaques. The angiostatic parameter endostatin is able to inhibit angiogenesis in tissue as well as in plaques and therefore plays an important role in physiological and pathological neovascularisation. The aim of the present study was to investigate sex-specific differences and the influence of exercise on circulating endostatin levels in patients suffering from diabetes, and control subjects.
In total, 42 T2DM-patients and 45 control subjects were investigated. They underwent a graded physical stress test (ergometry). Serum endostatin levels were measured in venous blood at rest and directly after reaching maximum workload.
Females showed significantly higher endostatin levels at baseline measurements compared to men, independently of their underlying disease. In both female and male T2DM-patients endostatin levels were significantly lower compared to controls. Both groups and sexes showed a significant increase of endostatin after physical stress, whereas the extent of endostatin-increase was between 10.59-15.05%.
Middle-aged healthy female individuals as well as female T2DM-patients showed higher circulating serum endostatin levels compared to males, suggesting a hormonal influence on baseline circulating endostatin amounts. Exercise-induced increase in endostatin is also observable in patients suffering from T2DM. Concerning vascularisation, lower endostatin levels in T2DM might be advantageous. Concerning plaque stability, lower levels might be prejudicial.
Clinical Trial Registration-URL: http://clinicaltrials.gov/ct2/results?term=NCT01165515.
2型糖尿病（T2DM）常与冠状动脉的动脉粥样硬化改变相关，最显著的是斑块。血管生成抑制参数内皮抑素能够抑制组织以及斑块中的血管生成，因此在生理和病理性新生血管形成中起重要作用。本研究的目的是调查糖尿病患者和对照受试者中循环内皮抑素水平的性别差异以及运动的影响。
共调查了42名T2DM患者和45名对照受试者。他们接受了分级体力应激试验（踏车运动试验）。在静息状态下以及达到最大工作量后立即采集静脉血，测定血清内皮抑素水平。
与男性相比，女性在基线测量时内皮抑素水平显著更高，与她们潜在的疾病无关。在女性和男性T2DM患者中，内皮抑素水平均显著低于对照组。两组和两性在体力应激后内皮抑素均显著增加，而内皮抑素增加的幅度在10.59 - 15.05%之间。
与男性相比，中年健康女性个体以及女性T2DM患者的循环血清内皮抑素水平更高，提示激素对基线循环内皮抑素量有影响。在T2DM患者中也可观察到运动诱导的内皮抑素增加。关于血管生成，T2DM中较低的内皮抑素水平可能是有利的。关于斑块稳定性，较低水平可能是有害的。
临床试验注册网址：http://clinicaltrials.gov/ct2/results?term=NCT01165515 。
