长期耐力运动可降低50至60岁超重男性体内的抗血管生成内皮抑素信号。

Long-term endurance exercise decreases antiangiogenic endostatin signalling in overweight men aged 50-60 years.

作者信息

Brixius K, Schoenberger S, Ladage D, Knigge H, Falkowski G, Hellmich M, Graf C, Latsch J, Montie G L, Prede G L, Bloch W

机构信息

Department of Molecular and Cellular Sport Medicine, German Sport University, Cologne, Germany.

出版信息

Br J Sports Med. 2008 Feb;42(2):126-9; discussion 129. doi: 10.1136/bjsm.2007.035188. Epub 2007 Jul 23.

DOI:10.1136/bjsm.2007.035188

PMID:17646243

Abstract

BACKGROUND

Endurance training may decrease the risk of coronary artery disease. It has been speculated that these effects may be due to an exercise-induced stimulation of angiogenesis. The underlying mechanisms are not yet clear. Therefore, using ELISA, we investigated the plasma level of vascular endothelial growth factor (VEGF, angiogenic factor) and endostatin (antiangiogenic factor) in a group of untrained men aged 50-60 years with obesity.

METHODS

All men were randomised into a "running" group (training 3 times/week, 60 min each, n = 7), a "cycling" group ( training 3 times/week, 90 min each, n = 7) and a sedentary control group ( n = 7). Both training groups worked at moderate intensity (2-4 mmol/l lactate). The intervention had a duration of 6 months. Before and after this period, blood samples were taken from the participants at rest and they underwent a medical investigation.

RESULTS

Body mass index (BMI), systolic and diastolic blood pressure, and plasma levels of VEGF and endostatin were comparable in all three groups. Endurance training significantly reduced BMI in both exercise groups (mean (SEM) before v after 29.7 (0.7) v 29.1 (0.6) kg/m2 and 31.1 (0.7) v 30.1 (0.9) kg/m2 for the running and cycling groups respectively) but not in the control group (30.0 (1.0) v 30.2 (0.8) kg/m2). Endurance training did not influence VEGF plasma level (before v after 1.3 (0.4) v 1.5 (0.2) ng/ml for the running group; 1.6 (0.3) v 1.5 (0.2) ng/ml for the cycling group; and 2.5 (0.6) v 2.1 (0.7) ng/ml for the control group). Plasma level of endostatin was significantly reduced in both exercise groups (mean (SEM) before v after: 20.9 (1.6 v 17.5 (1.0) ng/ml and 21.3 (1.4 v 18.0 (1.6) ng/ml for the running and cycling groups respectively) but not in controls (19.7 (1.3 v 17.7 (1.1 ng/ml).

CONCLUSIONS

Endurance training may reduce the antiangiogenic mechanisms in men aged 50-60 years by reducing endostatin plasma level and this may subsequently decrease the risk of cardiovascular disease.

摘要

背景

耐力训练可能会降低冠状动脉疾病的风险。据推测，这些影响可能归因于运动诱导的血管生成刺激。其潜在机制尚不清楚。因此，我们使用酶联免疫吸附测定法（ELISA），对一组年龄在50 - 60岁的肥胖未训练男性的血浆血管内皮生长因子（VEGF，血管生成因子）和内皮抑素（抗血管生成因子）水平进行了研究。

方法

所有男性被随机分为“跑步”组（每周训练3次，每次60分钟，n = 7）、“骑行”组（每周训练3次，每次90分钟，n = 7）和久坐对照组（n = 7）。两个训练组均以中等强度（乳酸浓度2 - 4 mmol/l）进行训练。干预持续6个月。在此期间前后，在参与者休息时采集血样，并对他们进行医学检查。

结果

三组的体重指数（BMI）、收缩压和舒张压以及VEGF和内皮抑素的血浆水平相当。耐力训练使两个运动组的BMI显著降低（跑步组训练前均值（标准误）为29.7（0.7）kg/m²，训练后为29.1（0.6）kg/m²；骑行组训练前为31.1（0.7）kg/m²，训练后为30.1（0.9）kg/m²），但对照组未降低（30.0（1.0）kg/m²对30.2（0.8）kg/m²）。耐力训练未影响VEGF血浆水平（跑步组训练前为1.3（0.4）ng/ml，训练后为1.5（0.2）ng/ml；骑行组训练前为1.6（0.3）ng/ml，训练后为1.5（0.2）ng/ml；对照组训练前为2.5（0.6）ng/ml，训练后为2.1（0.7）ng/ml）。两个运动组的内皮抑素血浆水平均显著降低（跑步组训练前均值（标准误）为20.9（1.6）ng/ml，训练后为17.5（1.0）ng/ml；骑行组训练前为21.3（1.4）ng/ml，训练后为18.0（1.6）ng/ml），但对照组未降低（19.7（1.3）ng/ml对17.7（1.1）ng/ml）。