Zhang Haiyan, Sun Tianhong
Dongying District Maternal and Child Health Hospital, Department of Gynaecology and Obstetrics, Dongying, Shandong, China.
Evid Based Complement Alternat Med. 2022 Jul 9;2022:4247412. doi: 10.1155/2022/4247412. eCollection 2022.
To investigate the correlation of blood glucose and islet function with serum retinol-binding protein 4, serum cystatin C, and nesfatin-1 levels in women with gestational diabetes mellitus.
Between June 2018 and June 2020, 70 patients with gestational diabetes mellitus were included in a study group and 70 healthy pregnant women were recruited into a healthy group. Alterations in fasting blood glucose (FPG), glycated hemoglobin (HbA1c), fasting serum insulin (FINS), homeostatic model assessment for insulin resistance (HOMA-IR), serum retinol-binding protein 4 (RBP4), serum cystatin C (CysC), and nesfatin-1 of all eligible participants were analyzed, and the occurrence of complications was recorded. Correlation analysis of serum RBP4, serum CysC, and nesfatin-1 levels with blood glucose and islet function in women with gestational diabetes mellitus was performed.
Gestational diabetes mellitus was associated with significantly higher levels of FPG, HbA1c, and HOMA-IR and lower levels of FINS (6.58 ± 1.41, 9.24 ± 1.09, 3.21 ± 2.03, 8.23 ± 2.21) versus a healthy condition (5.23 ± 0.85, 7.61 ± 0.67, 2.42 ± 1.14, 10.54 ± 2.15) ( < 0.05). Women with gestational diabetes mellitus showed significantly higher levels of serum RBP4, serum CysC, and nesfatin-1 (62.45 ± 7.86, 1.95 ± 0.59, 2.65 ± 0.49) versus healthy pregnant women (45.48 ± 6.15, 1.03 ± 0.67, 1.42 ± 0.62) ( < 0.05). With serum RBP4, serum CysC, and nesfatin-1 as dependent variables, univariate correlation analysis showed that serum RBP4, serum CysC, and nesfatin-1 levels were positively correlated with FPG and HbA1c levels and HOMA-IR, and negatively correlated with FINS in women with gestational diabetes mellitus ( < 0.05). Gestational diabetes mellitus resulted in a significantly higher incidence of preterm delivery, cesarean section, excess amniotic fluid, and premature rupture of membranes versus a healthy status ( < 0.05).
Glucose metabolism and islet function in women with gestational diabetes are significantly correlated with serum RBP4, serum CysC, and nesfatin-1 levels, which shows great potential for the prevention and treatment of gestational diabetes mellitus and perinatal complications.
探讨妊娠糖尿病患者血糖及胰岛功能与血清视黄醇结合蛋白4、血清胱抑素C和nesfatin-1水平的相关性。
2018年6月至2020年6月，将70例妊娠糖尿病患者纳入研究组，70例健康孕妇纳入健康组。分析所有符合条件参与者的空腹血糖（FPG）、糖化血红蛋白（HbA1c）、空腹血清胰岛素（FINS）、胰岛素抵抗稳态模型评估（HOMA-IR）、血清视黄醇结合蛋白4（RBP4）、血清胱抑素C（CysC）和nesfatin-1的变化，并记录并发症的发生情况。对妊娠糖尿病患者血清RBP4、血清CysC和nesfatin-1水平与血糖及胰岛功能进行相关性分析。
与健康状态相比，妊娠糖尿病患者的FPG、HbA1c和HOMA-IR水平显著升高，FINS水平降低（分别为6.58±1.41、9.24±1.09、3.21±2.03、8.23±2.21，而健康状态为5.23±0.85、7.61±0.67、2.42±1.14、10.54±2.15）（P<0.05）。与健康孕妇相比，妊娠糖尿病患者的血清RBP4、血清CysC和nesfatin-1水平显著升高（分别为62.45±7.86、1.95±0.59、2.65±0.49，而健康孕妇为45.48±6.15、1.03±0.67、1.42±0.62）（P<0.05）。以血清RBP4、血清CysC和nesfatin-1为因变量，单因素相关性分析显示，妊娠糖尿病患者血清RBP4、血清CysC和nesfatin-1水平与FPG、HbA1c水平及HOMA-IR呈正相关，与FINS呈负相关（P<0.05）。与健康状态相比，妊娠糖尿病导致早产、剖宫产、羊水过多和胎膜早破的发生率显著升高（P<0.05）。
妊娠糖尿病患者的糖代谢及胰岛功能与血清RBP4、血清CysC和nesfatin-1水平显著相关，这在妊娠糖尿病及围产期并发症的防治中具有很大潜力。
