Department of Obstetrics and Gynecology, Faculty of Medicine, Adnan Menderes University , Aydin , Turkey.
Gynecol Endocrinol. 2014 Mar;30(3):236-40. doi: 10.3109/09513590.2013.871519. Epub 2014 Jan 7.
The aim of this study is to compare galanin and IL-6 levels in pregnant women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT). Also association of insulin resistance markers, galanin and IL-6 was investigated.
The study registered 30 pregnant women with GDM and 30 pregnant women with NGT. Fasting venous blood samples were collected from all patients. Galanin and IL-6 levels were measured by an enzyme-linked immunosorbent assay.
Galanin and IL-6 levels were found higher in pregnant women with GDM (p < 0.001). A significant positive correlation was determined between galanin concentrations and glucose (r = 0.240, p = 0.065), insulin (r = 0.681, p < 0.001), HbA1c (r = -0.644, p < 0.001), IL-6 (r = 0.783, p < 0.05) and oral glucose challenge test results (r = 0.745, p < 0.001) in pregnant women included in study, whereas no significant association was determined between galanin and gestational age (r = 0.058, p = 0.662), body mass index (r = -0.019, p = 0.886).
Galanin and IL-6 were found to be significantly associated with insulin resistance markers in GDM, thus may play important roles in regulation of glucose hemostasis.
本研究旨在比较妊娠期糖尿病（GDM）和正常糖耐量（NGT）孕妇的甘丙肽和白细胞介素-6（IL-6）水平。还研究了胰岛素抵抗标志物、甘丙肽和 IL-6 的相关性。
该研究共纳入 30 例 GDM 孕妇和 30 例 NGT 孕妇。所有患者均采集空腹静脉血样。采用酶联免疫吸附试验测定甘丙肽和 IL-6 水平。
GDM 孕妇甘丙肽和 IL-6 水平均升高（p<0.001）。研究中纳入的孕妇甘丙肽浓度与血糖（r=0.240，p=0.065）、胰岛素（r=0.681，p<0.001）、糖化血红蛋白（HbA1c）（r=-0.644，p<0.001）、IL-6（r=0.783，p<0.05）和口服葡萄糖耐量试验结果（r=0.745，p<0.001）呈显著正相关，而甘丙肽与孕龄（r=0.058，p=0.662）、体重指数（r=-0.019，p=0.886）无显著相关性。
甘丙肽和 IL-6 与 GDM 胰岛素抵抗标志物显著相关，因此可能在血糖稳态调节中发挥重要作用。
