Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd MC 5723, Stanford, CA 94305-5723, United States.
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd MC 5723, Stanford, CA 94305-5723, United States.
J Affect Disord. 2014 Mar;156:214-8. doi: 10.1016/j.jad.2013.01.054. Epub 2013 Dec 21.
Brain-derived neurotrophic factor (BDNF) protein has been implicated in the pathophysiology of mood disorders, with early data suggesting that blood levels may vary by severity of mood symptoms. BDNF polymorphism, val66met, has also been implicated in mood disorders.
Euthymic women with bipolar disorder (BD) (n=47) and healthy control women (n=26), ages 18-45, were clinically rated using the Montgomery-Asberg Depression Rating Scale (MADRS) and sampled for plasma BDNF concentration, with a subset undergoing genetic analysis for the val66met.
BD and control groups did not differ on any demographic variables, nor in plasma BDNF levels or val66met polymorphism. Plasma BDNF concentration did not differ by val66met or BD subtype, nor was it correlated with age or illness duration. Within women with BD, lower plasma BDNF concentrations were significantly associated with higher MADRS scores, even after controlling for psychotropic medication use and illness duration.
The sample was relatively small and exclusive to women, with further research needed to investigate the links between BDNF markers and mood symptom severity in both men and women.
The study provides a gender-specific investigation of plasma BDNF levels and mood, and the results add further evidence of a significant interplay between BDNF markers and psychiatric symptomatology. Further, this association did not appear to be confounded by use of psychotropic medication. Studies with larger samples of both genders are needed to further delineate this relationship.
脑源性神经营养因子（BDNF）蛋白与心境障碍的病理生理学有关，早期数据表明，其血液水平可能因心境症状的严重程度而有所不同。BDNF 多态性 val66met 也与心境障碍有关。
18-45 岁的心境正常的女性双相障碍（BD）患者（n=47）和健康对照女性（n=26），使用蒙哥马利-阿斯伯格抑郁评定量表（MADRS）进行临床评定，并抽取血浆 BDNF 浓度样本，亚组进行 val66met 的基因分析。
BD 和对照组在任何人口统计学变量、血浆 BDNF 水平或 val66met 多态性上均无差异。BDN 浓度与 val66met 或 BD 亚型无关，也与年龄或疾病持续时间无关。在 BD 女性中，即使在考虑了精神药物使用和疾病持续时间后，较低的血浆 BDNF 浓度与较高的 MADRS 评分显著相关。
样本相对较小，仅限于女性，需要进一步研究以调查 BDNF 标志物与男性和女性情绪症状严重程度之间的联系。
该研究对血浆 BDNF 水平与情绪进行了性别特异性研究，结果进一步证明了 BDNF 标志物与精神症状之间存在显著的相互作用。此外，这种关联似乎不受精神药物使用的影响。需要有更大样本量的男女两性研究来进一步阐明这种关系。
