Oysu Cagatay, Tosun Ahmet, Yilmaz Huseyin Baki, Sahin-Yilmaz Asli, Korkmaz Deniz, Karaaslan Ahmet
Umraniye Education and Research Hospital, Department of Otolaryngology, Istanbul, Turkey.
Tuzla State Hospital, Otolaryngology Clinic, Istanbul, Turkey.
Auris Nasus Larynx. 2014 Jun;41(3):269-72. doi: 10.1016/j.anl.2013.12.002. Epub 2014 Jan 4.
To compare the effects of intranasal application of black seed (Nigella Sativa) oil (NSO) and isotonic sodium chloride solution (ISCS) on nasal symptoms of the elderly.
In this prospective, crossover randomized controlled trial, 42 geriatric patients with nasal dryness and related symptoms were randomized to receive either 2 weeks of isotonic sodium chloride solution (ISCS) followed by 2 weeks of N. sativa oil (NG oil) or the same treatment in the opposite order. There was a washout period of 3 weeks in between the treatment periods. Subjective symptoms including nasal dryness, burning, obstruction, itching and crusting were evaluated by a visual analog scale. Mucociliary function was evaluated with saccharin test.
Nasal dryness, obstruction and crusting improved significantly with the use of NSO compared to ISCS without any evidence of relevant carryover effects (p<0.05 for all for the difference in treatment). There was no significant difference between the effect of NSO and ISCS on nasal burning and itching (p>0.05 for all). There was no change in mucociliary clearance during any of the treatment periods.
NSO is a better alternative to ISCS to treat nasal mucosa symptoms due to aging.
比较经鼻应用黑种草籽油（NSO）和等渗氯化钠溶液（ISCS）对老年人鼻部症状的影响。
在这项前瞻性、交叉随机对照试验中，42例有鼻干燥及相关症状的老年患者被随机分为两组，一组先接受2周的等渗氯化钠溶液（ISCS）治疗，随后接受2周的黑种草籽油（NS油）治疗；另一组则顺序相反。两个治疗期之间有3周的洗脱期。通过视觉模拟量表评估包括鼻干燥、烧灼感、鼻塞、瘙痒和结痂在内的主观症状。用糖精试验评估黏液纤毛功能。
与ISCS相比，使用NSO后鼻干燥、鼻塞和结痂症状明显改善，且无任何相关遗留效应的证据（所有治疗差异p<0.05）。NSO和ISCS对鼻烧灼感和瘙痒的影响无显著差异（所有p>0.05）。在任何治疗期内，黏液纤毛清除功能均无变化。
NSO是治疗因衰老引起的鼻黏膜症状的比ISCS更好的选择。
