Hauptman Garrett, Ryan Matthew W
Department of Otolaryngology, The University of Texas Medical Branch, Galveston, TX, USA.
Otolaryngol Head Neck Surg. 2007 Nov;137(5):815-21. doi: 10.1016/j.otohns.2007.07.034.
To compare the effect of two saline nasal sprays on nasal patency and mucociliary clearance in patients with rhinosinusitis.
Randomized double-blind trial.
Eighty patients with rhinosinusitis at a tertiary care academic center had nasal patency and mucociliary clearance measured. Each patient was then treated with either physiological or hypertonic saline. Nasal patency and mucociliary clearance measurements were repeated after treatment. Subjective evaluation was also performed.
Both solutions improved saccharine clearance times (P < 0.0001). Buffered physiological saline significantly affected nasal airway patency (P = 0.006). Both solutions improved symptoms of nasal stuffiness (P < 0.0001) and nasal obstruction (P < 0.0001). Buffered hypertonic saline caused increased nasal burning/irritation compared with buffered physiological saline (P < 0.0001).
Buffered physiological and buffered hypertonic saline nasal sprays both improve mucociliary clearance, which is beneficial for treatment of rhinosinusitis. Additionally, buffered physiological saline improves nasal airway patency, whereas buffered hypertonic saline has no effect. Both solutions provide symptomatic relief, but buffered hypertonic saline is more irritating.
比较两种鼻腔喷雾剂对鼻窦炎患者鼻腔通畅度和黏液纤毛清除功能的影响。
随机双盲试验。
在一家三级医疗学术中心，对80例鼻窦炎患者测量其鼻腔通畅度和黏液纤毛清除功能。随后，每位患者分别接受生理性盐水或高渗盐水治疗。治疗后重复测量鼻腔通畅度和黏液纤毛清除功能，并进行主观评估。
两种溶液均缩短了糖精清除时间（P < 0.0001）。缓冲生理性盐水对鼻气道通畅度有显著影响（P = 0.006）。两种溶液均改善了鼻阻塞症状（P < 0.0001）和鼻塞症状（P < 0.0001）。与缓冲生理性盐水相比，缓冲高渗盐水导致鼻腔烧灼感/刺激感增加（P < 0.0001）。
缓冲生理性盐水鼻腔喷雾剂和缓冲高渗盐水鼻腔喷雾剂均能改善黏液纤毛清除功能，这对鼻窦炎治疗有益。此外，缓冲生理性盐水可改善鼻气道通畅度，而缓冲高渗盐水则无此作用。两种溶液均能缓解症状，但缓冲高渗盐水刺激性更强。
