Nemati Shadman, Masroorchehr Mohammadreza, Elahi Homayoon, Kamalinejad Mohammad, Ebrahimi Seyedeh Matin, Akbari Maryam
Department of Otolaryngology and Head and Neck Surgery, Otorhinolaryngology Research Center, School of Medicine, Amiralmomenin Hospital, Guilan University of Medical Sciences, 17 Shahrivar Ave, Rasht, Guilan 4139637459 Iran.
Department of Pharmacognosy, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.
Indian J Otolaryngol Head Neck Surg. 2021 Dec;73(4):455-460. doi: 10.1007/s12070-020-02296-9. Epub 2021 Jan 2.
Chronic rhinosinusitis (CRS) causes long-term discomfort for patients, and due to the frequent relapses and dissatisfaction with current treatments, CRS patients pay more attention to herbal-traditional remedies nowadays. seed has a special place in Traditional Persian medicine because of its therapeutic and clinical applications. Therefore, we decided to evaluate the effect of seed extract on clinical symptoms of CRS patients. In a double-blind controlled clinical trial on CRS patients referred to otolaryngology clinics of Firoozgar and Amiralmomenin hospitals, all the patients used nasal drops of the (drug) or sesame oil extract (placebo), and standard SNOT-22 questionnaire completed on days 0 and 28th of study. Data collected and statistical analysis performed by SPSS software. Level of significance was considered as < 0.05. Out of 53 subjects (33 male and 20 female), 27 were assigned in the drug group and 26 in the placebo group. The mean SNOT-22 score on the 28th day was 19.08 ± 13.21 in the drug group, and in the placebo group, the mean was 37.15 ± 21.47 ( = 0.001). extract was particularly effective in improving the feeling of pain, pressure or fullness, numbness and congestion in the nose, and reduction of bad breath. The results of our study indicated that the seed nasal drop significantly improved the symptoms of CRS-especially, four major and one minor symptoms- and improved the quality of life of the patients.
慢性鼻-鼻窦炎（CRS）给患者带来长期不适，且由于频繁复发以及对当前治疗效果不满意，CRS患者如今更加关注传统草药疗法。[种子名称]因其治疗和临床应用在传统波斯医学中占有特殊地位。因此，我们决定评估[种子名称]提取物对CRS患者临床症状的影响。在一项针对转诊至菲罗兹加尔医院和阿米尔·阿尔莫门宁医院耳鼻喉科诊所的CRS患者的双盲对照临床试验中，所有患者使用[药物名称]滴鼻剂或芝麻油提取物（安慰剂），并在研究的第0天和第28天完成标准的SNOT-22问卷。数据收集后通过SPSS软件进行统计分析。显著性水平设定为<0.05。在53名受试者（33名男性和20名女性）中，27人被分配到药物组，26人被分配到安慰剂组。药物组第28天的平均SNOT-22评分为19.08±13.21，安慰剂组的平均评分为37.15±21.47（P = 0.001）。[种子名称]提取物在改善疼痛、压迫感或胀满感、麻木感和鼻塞感以及减少口臭方面特别有效。我们的研究结果表明，[种子名称]滴鼻剂显著改善了CRS的症状——尤其是四项主要症状和一项次要症状——并提高了患者的生活质量。
