Richter C, Ter Beest G, Gisolf E H, VAN Bentum P, Waegemaekers C, Swanink C, Roovers E
Department of Infectious Diseases,Rijnstate Hospital,Arnhem,The Netherlands.
Municipal Health Service Arnhem,Arnhem,The Netherlands.
Epidemiol Infect. 2014 Oct;142(10):2140-6. doi: 10.1017/S0950268813003415. Epub 2014 Jan 7.
Migrants born in hepatitis B virus (HBV) and hepatitis C virus (HCV) endemic countries are at increased risk of being infected with these viruses. The first symptoms may arise when liver damage has already occurred. The challenge is to identify these infections early, since effective treatment has become available. In 2011 we conducted a screening project in first-generation migrants (FGMs) born in Afghanistan, Iran, Iraq, the former Soviet Republics, and Vietnam and living in Arnhem and Rheden. All participants were offered free blood screening for HBV and HCV. In total 959 participants were tested, with the country of origin known for 927, equating to 28·7% of all registered FGMs from the chosen countries. Nineteen percent (n = 176) had serological signs of past or chronic HBV infection and 2·2% (n = 21) had chronic HBV infection. The highest prevalence of chronic HBV infection was found in the Vietnamese population (9·5%, n = 12). Chronic HCV was found in two persons from the former Soviet Republics and one from Vietnam. Twenty-four percent (n = 5) of the newly identified patients with chronic HBV and one of the three patients with chronic HCV received treatment. Three of the patients, two with HCV and one with HBV, already had liver cirrhosis. The highest (9·5%) HBV prevalence was found in FGMs from Vietnam, indicating a high need for focusing on that particular immigrant population in order to identify more people with silent HBV infection. The fact that three patients already had liver cirrhosis underlines the necessity of early identification of HBV and HCV infection in risk groups.
出生在乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)流行国家的移民感染这些病毒的风险增加。最初的症状可能在肝脏已经受损时才出现。挑战在于尽早识别这些感染,因为有效的治疗方法已经出现。2011年,我们对出生在阿富汗、伊朗、伊拉克、前苏联共和国和越南且居住在阿纳姆和雷登的第一代移民(FGMs)开展了一项筛查项目。所有参与者都获得了免费的HBV和HCV血液筛查。总共对959名参与者进行了检测,其中927人的原籍国已知,这相当于来自所选国家的所有登记FGMs的28.7%。19%(n = 176)有既往或慢性HBV感染的血清学迹象,2.2%(n = 21)有慢性HBV感染。慢性HBV感染患病率最高的是越南人群(9.5%,n = 12)。在两名来自前苏联共和国的人和一名来自越南的人身上发现了慢性HCV。新确诊的慢性HBV患者中有24%(n = 5)以及三名慢性HCV患者中的一名接受了治疗。其中三名患者,两名患有HCV,一名患有HBV,已经出现肝硬化。在来自越南的FGMs中发现了最高的(9.5%)HBV患病率,这表明非常有必要关注这一特定移民群体,以便识别出更多无症状HBV感染的人。有三名患者已经出现肝硬化这一事实凸显了在高危人群中尽早识别HBV和HCV感染的必要性。