Rastin M, Mahmoudi M, Rezaee S A, Assarehzadegan M A, Tabasi N, Zamani S, Nosratabadi R, Haghmorad D, Sheikh A, Khazaee M, Panah H R
Immunology Research Center, BuAli Research Institute, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Indian J Med Microbiol. 2014 Jan-Mar;32(1):53-6. doi: 10.4103/0255-0857.124306.
Six major hepatitis C virus genotypes have been characterised, which vary in their geographical distribution. The prevalence of hepatitis C virus (HCV) in an area is not constant, and depends on the changes in route of infection, which may change over time. In this study, the distribution of HCV genotypes in Mashhad, the capital of Razavi Khorasan province in north-east of Iran was investigated. Mashhad is a holy city of Shiate Moslems, which attracts more than 20 million tourists and pilgrims every year.
Two hundred and seventy-eight HCV infected subjects (227 males and 51 females) were included in this study. HCV genotypes were analysed by type specific reverse transcriptase polymerase chain reaction (RT-PCR).
Genotype 3a was detected in 49.6%, 1a in 36.3%, 1b in 12.6% and 2a in 0.4%. Two HCV genotypes were detected in 1.1% cases; 1a +3a in 1%, 3a + 1b in 0.4%. Genotypes 2b and 3b were not detected in any samples.
We demonstrated that despite the previous reports on the frequency of HCV genotypes in Iran, 3a is the predominant genotype in Mashhad.
已鉴定出六种主要的丙型肝炎病毒基因型，它们在地理分布上有所不同。某地区丙型肝炎病毒（HCV）的流行率并非恒定不变，而是取决于感染途径的变化，而感染途径可能随时间发生改变。在本研究中，对伊朗东北部拉扎维霍拉桑省省会马什哈德的HCV基因型分布进行了调查。马什哈德是什叶派穆斯林的圣城，每年吸引超过2000万游客和朝圣者。
本研究纳入了278名HCV感染受试者（227名男性和51名女性）。通过型特异性逆转录酶聚合酶链反应（RT-PCR）分析HCV基因型。
检测到3a基因型的占49.6%，1a基因型的占36.3%，1b基因型的占12.6%，2a基因型的占0.4%。1.1%的病例检测到两种HCV基因型；1a + 3a的占1%，3a + 1b的占0.4%。未在任何样本中检测到2b和3b基因型。
我们证明，尽管之前有关于伊朗HCV基因型频率的报道，但在马什哈德，3a是主要基因型。
